ID B9ELT8_SALSA Unreviewed; 346 AA.
AC B9ELT8;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Src kinase-associated phosphoprotein 2 {ECO:0000313|EMBL:ACM08485.1, ECO:0000313|RefSeq:NP_001139886.1};
GN Name=SKAP2 {ECO:0000313|EMBL:ACM08485.1};
GN Synonyms=skap2 {ECO:0000313|RefSeq:NP_001139886.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACM08485.1};
RN [1] {ECO:0000313|EMBL:ACM08485.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Head kidney {ECO:0000313|EMBL:ACM08485.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACM08485.1, ECO:0000313|RefSeq:NP_001139886.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Head kidney {ECO:0000313|EMBL:ACM08485.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACM08485.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Head kidney {ECO:0000313|EMBL:ACM08485.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001139886.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SKAP family.
CC {ECO:0000256|ARBA:ARBA00005864}.
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DR EMBL; BT056613; ACM08485.1; -; mRNA.
DR RefSeq; NP_001139886.1; NM_001146414.1.
DR STRING; 8030.ENSSSAP00000019608; -.
DR PaxDb; 8030-ENSSSAP00000019608; -.
DR GeneID; 100286475; -.
DR KEGG; sasa:100286475; -.
DR CTD; 8935; -.
DR OrthoDB; 2968233at2759; -.
DR Proteomes; UP000087266; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 6.10.250.220; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR037781; SKAP_fam.
DR PANTHER; PTHR15129:SF2; SRC KINASE-ASSOCIATED PHOSPHOPROTEIN 2; 1.
DR PANTHER; PTHR15129; SRC-ASSOCIATED ADAPTOR PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW B-cell activation {ECO:0000256|ARBA:ARBA00022936};
KW Kinase {ECO:0000313|EMBL:ACM08485.1, ECO:0000313|RefSeq:NP_001139886.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192};
KW Transferase {ECO:0000313|EMBL:ACM08485.1,
KW ECO:0000313|RefSeq:NP_001139886.1}.
FT DOMAIN 106..209
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 284..345
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 51..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..272
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 346 AA; 39885 MW; 1A3A9F4336AE1929 CRC64;
MRSIPEELTT LISDLEDFLF DGLKGENLSK KAKEKREAFI KRIKEVKSGY PQEFNEKRDA
EDSEEDEVED SNNDGWSLHS ERTDKEDETC EGAQQSLAVA AQDLQSVFKA GHLEKRRKDH
SFFGTEWQKR WCALSNQTFY YYGSEKDKQQ KGEFAIDGYS VKMNNTLRKD SKKDCCFEIS
SSDKRVYQFC ASSQKEAEEW VEQIDFVLRD MSGVIPLDEE DQETYDDIGA VEAEPIDDDI
YEELPEEDMS TPPLPTPPKP KVEPPTPHSK PTPPTTATVN KTTDYQNYYQ GIWDCTGDQP
DELSFKRGDS IYILSKEYQN YGWWIGEMKG SVGIVPKEYL MELYAI
//
