ID B9ET11_ORYSJ Unreviewed; 1481 AA.
AC B9ET11;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=Tower domain-containing protein {ECO:0000259|SMART:SM01341};
GN ORFNames=OsJ_00498 {ECO:0000313|EMBL:EEE53927.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947 {ECO:0000313|EMBL:EEE53927.1};
RN [1] {ECO:0000313|EMBL:EEE53927.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C., Chen H., Xu Z., Li H., Huang H., Zhang F., Xu H.,
RA Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W.,
RA Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L.,
RA Zheng W., Hao B., Liu S., Wang W., Yuan L., Cao M., McDermott J.,
RA Samudrala R., Wang J., Wong G.K., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [2] {ECO:0000313|EMBL:EEE53927.1}
RP NUCLEOTIDE SEQUENCE.
RA Wang J., Li R., Fan W., Huang Q., Zhang J., Zhou Y., Hu Y., Zi S., Li J.,
RA Ni P., Zheng H., Zhang Y., Zhao M., Hao Q., McDermott J., Samudrala R.,
RA Kristiansen K., Wong G.K.-S.;
RT "Improved gene annotation of the rice (Oryza sativa) genomes.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CM000138; EEE53927.1; -; Genomic_DNA.
DR Proteomes; UP000007752; Chromosome 1.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR CDD; cd04494; BRCA2DBD_OB2; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 4.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR048262; BRCA2_OB_2_dom.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR015205; Tower_dom.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF00634; BRCA2; 5.
DR SMART; SM01341; Tower; 1.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS50138; BRCA2_REPEAT; 4.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1119..1159
FT /note="Tower"
FT /evidence="ECO:0000259|SMART:SM01341"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..42
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1481 AA; 160923 MW; 00D511E93775A007 CRC64;
MQRRWQVWGK PDGSLVWVPA SDGPPPPAAA ASEAPLPRPD PQPAATELGE ARSGDAIPEG
PGAADGCSVP SMADLFNQAL DKLVAADGMA EAIEDSGKGA VFCTGLGGSV AVSERAVERA
KALVGEVAEE ISNERRQPFG DGSNLECGLG ESNVSFKGGV HKDSLSPMFQ TGSGKMVSLS
KGSIQKARAV LEGNAENSSV IAVQSMFHTG LVRPDPVSRS STDNAMTVLE GQTNPKQGDV
ADVYDKENFP LFQTGSGKAV SVSVASIQKA KAVLEQNNTE NTEDFGRPDQ SLIFQTGSRR
PVLISERSSS VVKDGGAENI GHGDTNVSTT TFQTETPTSV LMSGGLTMND RSVTPEGGVS
MQGNFLEADG HLPLFQTGLG RSISVSKGSI KRASALLEPR NITKELEDEA HSDDGCATPM
FKTGSGRSIT ASENSRKKAH VVLEGEEPVK NVNNDTGEAI APMLHAGMQK FAPQNRNSSH
KAITLMEQGS SMKEEYIDRG NEPPMFRTGS GKSVLISHSS VQKARAVLEE EGNMKKENHK
QLSNVDKYIP IFTSPLKTSY ARTVHISSVG VSRAATLLGL EENTLSTQLL GHVGDKLGTK
ITVERENSEH QFGVASVSGI SGGCPISSGP AENQVLMDPH QHFAFSKTTF SDSSEQAIRF
STAGGRTMAI SSDALQRAKN LLGESDLEVS PNNLLGHSSA SACKENIQNS TGLRKEGEPD
LLKSRGNSKT EPAQFSIPAK PDRKHTDSLE YAVPDATLAN GNSVRLHAAR DFHPINEIPK
ISKPSSRCSF GTENASDTKD KARRLQMPSG PLIDITNYID THSVNTDYLA GSSHLSTSII
HPLLTEDVTD EVKLMDAKKA EKYKFKTDTG AEEFQKMLLA CGASLTYTTK EWVSNHYKWI
VWKLASLERC YPTRAAGKFL KVGNVLEELK YSMLGITGEV NNGHRSAIKK ILEGNASPSL
MMVLCISAIY SCPDLNNSKP EDDRAHTDDD NSENKSLRPA KRNMSTKIEL TDGWYSLDAS
LDLALLEQLE KRKLFIGQKL RIWGASLCGW AGPVSFHEAS GTVKLMIHIN GTYRARWDET
LGLCKHAGVP LAFKCIKASG GRVPRTLVGV TRIYPVMYRE RFSDGRFVVR SERMERKALQ
LYHQRVSKIA EDIQSEHGEH CDNTDDNDEG AKICKMLERA AEPEILMSSM SSEQLLSFSY
YQEKQKIVRQ NEVAKKVENA LKVAGLSSRD VTPFLKVRVT GLISKHSATK SGCREGLITI
WNPTEKQKSD LVEGQIYSVT GLLASSYFTE VSYLSGRGSS TAWTPLATAQ TTNFEPFFTP
RKAVELSHFG EVPLTSEFDI AGVILYVGNV YLLNNQNRQW LFLTDGSKFI SGEKYEEQDD
CLLAVSFSSK TTGEDSAFFN YALSGHIVGF SNLVKRDKDQ MRHVWVAEAT ESSTYSLSHE
IPKKSHLKEA ATSAEKWASN SHPMIQHLKE RVLQIVGDSG G
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