ID B9HUU6_POPTR Unreviewed; 559 AA.
AC B9HUU6;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=POPTR_010G085900 {ECO:0000313|EMBL:PNT15455.1};
OS Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp.
OS trichocarpa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus.
OX NCBI_TaxID=3694 {ECO:0000313|EMBL:PNT15455.1, ECO:0000313|Proteomes:UP000006729};
RN [1] {ECO:0000313|EMBL:PNT15455.1, ECO:0000313|Proteomes:UP000006729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nisqually {ECO:0000313|Proteomes:UP000006729};
RX PubMed=16973872; DOI=10.1126/science.1128691;
RA Tuskan G.A., Difazio S., Jansson S., Bohlmann J., Grigoriev I.,
RA Hellsten U., Putnam N., Ralph S., Rombauts S., Salamov A., Schein J.,
RA Sterck L., Aerts A., Bhalerao R.R., Bhalerao R.P., Blaudez D., Boerjan W.,
RA Brun A., Brunner A., Busov V., Campbell M., Carlson J., Chalot M.,
RA Chapman J., Chen G.L., Cooper D., Coutinho P.M., Couturier J., Covert S.,
RA Cronk Q., Cunningham R., Davis J., Degroeve S., Dejardin A.,
RA Depamphilis C., Detter J., Dirks B., Dubchak I., Duplessis S., Ehlting J.,
RA Ellis B., Gendler K., Goodstein D., Gribskov M., Grimwood J., Groover A.,
RA Gunter L., Hamberger B., Heinze B., Helariutta Y., Henrissat B.,
RA Holligan D., Holt R., Huang W., Islam-Faridi N., Jones S.,
RA Jones-Rhoades M., Jorgensen R., Joshi C., Kangasjarvi J., Karlsson J.,
RA Kelleher C., Kirkpatrick R., Kirst M., Kohler A., Kalluri U., Larimer F.,
RA Leebens-Mack J., Leple J.C., Locascio P., Lou Y., Lucas S., Martin F.,
RA Montanini B., Napoli C., Nelson D.R., Nelson C., Nieminen K., Nilsson O.,
RA Pereda V., Peter G., Philippe R., Pilate G., Poliakov A., Razumovskaya J.,
RA Richardson P., Rinaldi C., Ritland K., Rouze P., Ryaboy D., Schmutz J.,
RA Schrader J., Segerman B., Shin H., Siddiqui A., Sterky F., Terry A.,
RA Tsai C.J., Uberbacher E., Unneberg P., Vahala J., Wall K., Wessler S.,
RA Yang G., Yin T., Douglas C., Marra M., Sandberg G., Van de Peer Y.,
RA Rokhsar D.;
RT "The genome of black cottonwood, Populus trichocarpa (Torr. & Gray).";
RL Science 313:1596-1604(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Folate-
CC biopterin transporter (TC 2.A.71) family.
CC {ECO:0000256|ARBA:ARBA00007015}.
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DR EMBL; CM009299; PNT15455.1; -; Genomic_DNA.
DR RefSeq; XP_002314687.1; XM_002314651.2.
DR AlphaFoldDB; B9HUU6; -.
DR EnsemblPlants; Potri.010G085900.1.v4.1; Potri.010G085900.1.v4.1; Potri.010G085900.v4.1.
DR GeneID; 7474196; -.
DR Gramene; Potri.010G085900.1.v4.1; Potri.010G085900.1.v4.1; Potri.010G085900.v4.1.
DR KEGG; pop:7474196; -.
DR eggNOG; ENOG502QPYM; Eukaryota.
DR HOGENOM; CLU_018563_3_0_1; -.
DR InParanoid; B9HUU6; -.
DR OrthoDB; 241511at2759; -.
DR Proteomes; UP000006729; Chromosome 10.
DR ExpressionAtlas; B9HUU6; baseline and differential.
DR GO; GO:0009941; C:chloroplast envelope; IEA:EnsemblPlants.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015231; F:5-formyltetrahydrofolate transmembrane transporter activity; IEA:EnsemblPlants.
DR GO; GO:0008517; F:folic acid transmembrane transporter activity; IEA:EnsemblPlants.
DR GO; GO:0015350; F:methotrexate transmembrane transporter activity; IEA:EnsemblPlants.
DR CDD; cd17484; MFS_FBT; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR039309; BT1.
DR InterPro; IPR004324; FBT.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00788; fbt; 1.
DR PANTHER; PTHR31585; FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC; 1.
DR PANTHER; PTHR31585:SF0; FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC; 1.
DR Pfam; PF03092; BT1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 38..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..53
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 60476 MW; BE2E6E040DC2FCF6 CRC64;
MASTNSRSSF SILPSHQNPI LSSLTLSPHF QIHRKRLSIV SHRRTRRRPR RKLAGGKDMS
VAINMPTPSH RRDKSQDSVL DSTNSAGERE MLTADVEGEM SSTSKNAMRI SKYLISRICF
GVDLSPDNIA VAMVYFVQGV LGLARLAVSF YLKDDLHLEP AETAVISGFS ALPWLIKPLY
GFISDSVPLF GYRRRSYLVL SGLLGALSWS LMSTFVDSKY SAAFCILLGS LSVAFSDVVV
DSMVVERARG ESQSMSGSLQ SLCWGSSAFG GIVSSYFSGS LVDAYGVRFV FGVTALLPLI
TSAVAVLVRE QRVLGPASGP SLALPGSGFL ESSKQHIVQL WDAVKQPNVF LPTLFIFLWQ
ATPQSDSAMF FFTTNKLGFT PEFLGRVKLV TSVASLLGVG LYNGFLKNVP LRKIFVATTV
TGTALGMTQV FLVTGLNRKF GISDEWFAIG DSLILTVLGQ VSFMPVLVLA AKLCPEGMEA
TLFATLMSIS NGGSVLGGLI GAGLTQFFGV TKDNFDNLAF LIILCNLSSL LPLPLLGLLP
NDRPDAIPKE SRDIEMKSN
//
