ID B9K8U3_THENN Unreviewed; 790 AA.
AC B9K8U3;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=ATP-dependent Clp protease, ATPase subunit {ECO:0000313|EMBL:ACM23376.1};
GN OrderedLocusNames=CTN_1200 {ECO:0000313|EMBL:ACM23376.1};
OS Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E).
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Thermotogaceae;
OC Thermotoga.
OX NCBI_TaxID=309803 {ECO:0000313|EMBL:ACM23376.1, ECO:0000313|Proteomes:UP000000445};
RN [1] {ECO:0000313|Proteomes:UP000000445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E
RC {ECO:0000313|Proteomes:UP000000445};
RA Lim S.K., Kim J.S., Cha S.H., Park B.C., Lee D.S., Tae H.S., Kim S.-J.,
RA Kim J.J., Park K.J., Lee S.Y.;
RT "The genome sequence of the hyperthermophilic bacterium Thermotoga
RT neapolitana.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACM23376.1, ECO:0000313|Proteomes:UP000000445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E
RC {ECO:0000313|Proteomes:UP000000445};
RX PubMed=19129632; DOI=10.1271/bbb.80567;
RA Lee D., Seo H., Park C., Park K.;
RT "WeGAS: a web-based microbial genome annotation system.";
RL Biosci. Biotechnol. Biochem. 73:213-216(2009).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
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DR EMBL; CP000916; ACM23376.1; -; Genomic_DNA.
DR RefSeq; WP_015919691.1; NC_011978.1.
DR AlphaFoldDB; B9K8U3; -.
DR STRING; 309803.CTN_1200; -.
DR KEGG; tna:CTN_1200; -.
DR eggNOG; COG0542; Bacteria.
DR HOGENOM; CLU_005070_4_1_0; -.
DR Proteomes; UP000000445; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:ACM23376.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:ACM23376.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 4..151
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT DOMAIN 418..453
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT COILED 414..464
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 790 AA; 90138 MW; 65FB0BA430429919 CRC64;
MFNLEEYTEK AQKVMMSIQD IMTRYRQNQL SSEHILLAIL EEGNNVGVEL LKEMNVDINK
LKDEVETFIG KYGVRVPEGT SVSQIFITPD ARHVIEKARE EARRMGDSKI GTEHLLLGMV
LSPDSTAFRI LSRYGVTPER VYEAIRKIRA TGRTDEAENI EALARFTVDL TQLAREKKLM
PVVDREKEIR RVIQILSRRT KNNPVLIGDP GVGKTAVVEG LAQRIVEGKV PLFLRNVRVL
KLDMGRLVAG TRFRGDFEER LKRLLDELKR KKGEVILFID EVHTVVGAGA AEGALDAANI
MKPELTTGEI QIIGATTVEE YRKYIEKDRA LERRFQPVLV EEPTVEQTVE ILKGLRKVFE
DHHKVKITDD ALEAAAKLSA RYITNRFLPD KAVDLIDEAA SYVRLESSYP SEEILKLEEK
MRELEDRINA AVVKGEYEEA AKLKVELQKL KEEYEKARKS QEKVEPVVNE DIVAKIVEQW
TGIPVSRIME SEKDKLLKLE ELIHQRLVNQ EEAVRMVART IRRARVGIKN PRRPIGVFLF
LGPTGVGKTE LARTLADVLF GSEDAMIRLD MSEYMEKHSV ARLIGAPPGY VGYEEGGQLT
EAVRRRPYSV ILLDEIEKAH PDVFNILLQV FEDGRLTDGK GNTVDFRNTI IIMTSNIGSE
KILESQENVR LEIEKEIRNV FKPEFLNRID AIVYFKPLTM DEVKKIVEIM VKQLEDILKD
KRITLELTER AKEYLAEAGY VPSLGARPLR RIIELELESM IADKILEGEI KEGDHIVVDA
DEYGLKIERR
//
