ID B9M4Z8_GEODF Unreviewed; 502 AA.
AC B9M4Z8;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Anaerobic magnesium-protoporphyrin IX monomethyl ester oxidative cyclase-related enzyme {ECO:0000313|EMBL:ACM21682.1};
GN OrderedLocusNames=Geob_3339 {ECO:0000313|EMBL:ACM21682.1};
OS Geotalea daltonii (strain DSM 22248 / JCM 15807 / FRC-32) (Geobacter
OS daltonii).
OC Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC Geobacteraceae; Geotalea.
OX NCBI_TaxID=316067 {ECO:0000313|EMBL:ACM21682.1, ECO:0000313|Proteomes:UP000007721};
RN [1] {ECO:0000313|EMBL:ACM21682.1, ECO:0000313|Proteomes:UP000007721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22248 / JCM 15807 / FRC-32
RC {ECO:0000313|Proteomes:UP000007721};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA Kostka J., Richardson P.;
RT "Complete sequence of Geobacter sp. FRC-32.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001390; ACM21682.1; -; Genomic_DNA.
DR RefSeq; WP_012648410.1; NC_011979.1.
DR AlphaFoldDB; B9M4Z8; -.
DR STRING; 316067.Geob_3339; -.
DR KEGG; geo:Geob_3339; -.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_021572_4_0_7; -.
DR OrthoDB; 9762608at2; -.
DR Proteomes; UP000007721; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF17; MG-PROTOPORPHYRIN IX MONOMETHYL ESTER OXIDATIVE CYCLASE 66KD SUBUNIT; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000007721}.
FT DOMAIN 12..146
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 191..414
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 502 AA; 56498 MW; 54D6BF862C65170B CRC64;
MTIKRVALIT PPYHSGVVES AGTWLNVGLV YIAGALRAQG YEVDYYDAMS LWHKWPEIQE
RIEAFNPDVV ATTAYTASIV HAVELVRLAK SVNPQVVTVI GNVHATFCYE ELLSADHNVI
DYVVRGEGEV TLPSLLNCLN AGEDPAAVPG LAFYSGGSVI ATPKAPYIQD LDSLQAAWDL
VEWPIYTYRA KNNARLAIVS SSRGCQQKCS FCSQQLFWAQ TWRARSPENF IAELEMLNNK
YGVEVAMLSD EIPTFDRDRW VRILDLMIER KVGVKLLMET RVDDILRDAD IMDKYRKAGV
EHIYVGVEAG SQETLDLFKK DTKVEQSKLA IDIINNADIV SETSFVLGMP EDTPESIAAT
IELAKHYNPD MAFFLAIAPW PYAELYPQLE KYVVTKDYRK YNLVEPVLKP INMSVDELEK
ELGKAAQKFY MHKFQNLDKI RGWKKDFMLA VLDIFINHSY LAGQIKAAMK EGKEMPPEVK
ALIKTVKGHK SPAMHQAIAP IP
//
