ID B9PI44_TOXGV Unreviewed; 788 AA.
AC B9PI44; A0A0F7V1Y6; B9Q684; S7V4P9;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=RNA methyltransferase {ECO:0000256|RuleBase:RU367087};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU367087};
GN ORFNames=BN1205_018460 {ECO:0000313|EMBL:CEL75260.1}, TGVEG_271190
GN {ECO:0000313|EMBL:ESS36176.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS36176.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|EMBL:ESS36176.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS36176.1};
RA Paulsen I.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ESS36176.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS36176.1};
RA Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA Roos D., Caler E., Lorenzi H.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEL75260.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:CEL75260.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|ARBA:ARBA00008361, ECO:0000256|RuleBase:RU367087}.
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DR EMBL; LN714498; CEL75260.1; -; Genomic_DNA.
DR EMBL; AAYL02000012; ESS36176.1; -; Genomic_DNA.
DR AlphaFoldDB; B9PI44; -.
DR STRING; 432359.B9PI44; -.
DR PaxDb; 5811-TGME49_071190; -.
DR EnsemblProtists; ESS36176; ESS36176; TGVEG_271190.
DR VEuPathDB; ToxoDB:TGVEG_271190; -.
DR eggNOG; KOG2899; Eukaryota.
DR OMA; SEECYCE; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR039772; Bin3-like.
DR InterPro; IPR010675; Bin3_C.
DR InterPro; IPR024160; BIN3_SAM-bd_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12315:SF0; 7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME; 1.
DR PANTHER; PTHR12315; BICOID-INTERACTING PROTEIN RELATED; 1.
DR Pfam; PF06859; Bin3; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51515; BIN3_SAM; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU367087};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU00848};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU367087}.
FT DOMAIN 135..580
FT /note="Bin3-type SAM"
FT /evidence="ECO:0000259|PROSITE:PS51515"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 84414 MW; 2B35038FA2A2AB32 CRC64;
MSSAGTSTGL QGNREAEGRA VSPAEHALDG MGFLGKSWSS NEYGSSCSSR RKRRCLHGNF
PAYYAGRRAF VRSHNCSQQS SVYMDRPADG CCRLSGGPAA EIDMCSAPVG PSNSYETHLC
TSELVQGHVG IRDIDPRLDA VLSSLGGIFF EGKDVLDIGC NAGCLCLATA GLLHARSVTG
VDIDEDLVAL ANSALEELRT LALRRHTVLS SLTCQKTVKS SVDHESPETS GSCVSASSPY
PGSETKRTDL DTGNCIISGS PAKATRNLVM TSAVGERLPT IPDLDRGCKD DKGLSGAPYG
ISEHPENPEN NSLKQSGGVS KRSPGSHFSQ VFGRLLWNAL VTEATTGEVR EPGLESTRLS
KTERRTKEVC DGHVPSNVQS GFTGMATSTG ISTRATDSTE REAAFPFNVS FHSTDIVGGL
ASQTSSAIVQ NEREHPSPLG SEECYCELLG TVSRAVGSLP KGALLSPGSF DIVICFSVTK
WIHLHHGDCG ILLLFSRLHA LLKPDGILLL EPQDWASYRR ARRLSSDFKQ QLHHIRLPPK
TFTSILTANS GSRKSQCSSC VICDAWSNDA KTAASTELSA VTDKQCEQYE PKSETAENGC
QCACRIVSSL IPPCDGSSQG LSAKKPVQPF VLMCSLNPWT NDVRISKHQQ SGAYGGTMWD
ESRAAADGRA APRPHQLSVD EVCKHGNVTA RKSDEGYLDG VFDDDQRCSQ APANHVFQKG
SEVVKSAEPK ISDAKAVREP KGRLSDRRIL VLRKSSSCFS VCCCTLKMLT SRAVGRCGPK
PINSQSQS
//
