ID B9S5X5_RICCO Unreviewed; 348 AA.
AC B9S5X5;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase, putative {ECO:0000313|EMBL:EEF41062.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:EEF41062.1};
GN ORFNames=RCOM_0655630 {ECO:0000313|EMBL:EEF41062.1};
OS Ricinus communis (Castor bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae;
OC Ricinus.
OX NCBI_TaxID=3988 {ECO:0000313|Proteomes:UP000008311};
RN [1] {ECO:0000313|Proteomes:UP000008311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Hale {ECO:0000313|Proteomes:UP000008311};
RX PubMed=20729833; DOI=10.1038/nbt.1674;
RA Chan A.P., Crabtree J., Zhao Q., Lorenzi H., Orvis J., Puiu D.,
RA Melake-Berhan A., Jones K.M., Redman J., Chen G., Cahoon E.B., Gedil M.,
RA Stanke M., Haas B.J., Wortman J.R., Fraser-Liggett C.M., Ravel J.,
RA Rabinowicz P.D.;
RT "Draft genome sequence of the oilseed species Ricinus communis.";
RL Nat. Biotechnol. 28:951-956(2010).
CC -!- SIMILARITY: Belongs to the HIBADH-related family. NP60 subfamily.
CC {ECO:0000256|ARBA:ARBA00007598}.
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DR EMBL; EQ973876; EEF41062.1; -; Genomic_DNA.
DR AlphaFoldDB; B9S5X5; -.
DR STRING; 3988.B9S5X5; -.
DR eggNOG; KOG0409; Eukaryota.
DR InParanoid; B9S5X5; -.
DR Proteomes; UP000008311; Unassembled WGS sequence.
DR GO; GO:0009507; C:chloroplast; IBA:GO_Central.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0030267; F:glyoxylate reductase (NADP+) activity; IBA:GO_Central.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580:SF10; GLYOXYLATE_SUCCINIC SEMIALDEHYDE REDUCTASE 2, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:EEF41062.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008311}.
FT DOMAIN 60..219
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 222..341
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
SQ SEQUENCE 348 AA; 36345 MW; 6568FBD9CDC90C7F CRC64;
MTLLVKINNS HSLLSTMCSS FCPQLPSHLR AIPISSFLTR QSFKAFSVSA SVKADGSSTR
VGFLGMGIMG TPMTQNLIKA GCDVTVWNRT KSKCDPLISL GAKYRPSPEE VAAASDVTFA
MLADPESAVE VACGKNGAAG GMGPGKGYVD VSTVDGGTSK LIGGHIKATG ASFLEAPVSG
SKKPAEDGQL IFLTAGDKPL YEIVAPFLDI MGKSRFYLGD VGNGAAMKLV VNMIMGSMMA
TFSEGILLGE KVGLDPNVIV EVVSQGAISA PMYSMKGPSM IKSIYPTAFP LKHQQKDLRL
ALGLAESVSQ PTPIAAAANE LYKVAKSHGL SDSDFSAVIE ALKVKLQS
//
