ID B9U101_CRYGA Unreviewed; 577 AA.
AC B9U101;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Lysophospholipase {ECO:0000256|RuleBase:RU362103};
DE EC=3.1.1.5 {ECO:0000256|RuleBase:RU362103};
DE Flags: Fragment;
GN Name=PLB1 {ECO:0000313|EMBL:ACB42025.1};
OS Cryptococcus gattii (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=552467 {ECO:0000313|EMBL:ACB42025.1};
RN [1] {ECO:0000313|EMBL:ACB42025.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AV54S {ECO:0000313|EMBL:ACB42037.1}, AV54W
RC {ECO:0000313|EMBL:ACB42036.1}, LA43 {ECO:0000313|EMBL:ACB42030.1},
RC LA84 {ECO:0000313|EMBL:ACB42031.1}, RAM002
RC {ECO:0000313|EMBL:ACB42028.1}, RB52 {ECO:0000313|EMBL:ACB42034.1}, and
RC WM1008 {ECO:0000313|EMBL:ACB42025.1};
RX PubMed=19517012; DOI=10.1371/journal.pone.0005862;
RA Ngamskulrungroj P., Gilgado F., Faganello J., Litvintseva A.P., Leal A.L.,
RA Tsui K.M., Mitchell T.G., Vainstein M.H., Meyer W.;
RT "Genetic diversity of the Cryptococcus species complex suggests that
RT Cryptococcus gattii deserves to have varieties.";
RL PLoS ONE 4:E5862-E5862(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|RuleBase:RU362103};
CC -!- SIMILARITY: Belongs to the lysophospholipase family.
CC {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
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DR EMBL; EU408668; ACB42025.1; -; Genomic_DNA.
DR EMBL; EU408671; ACB42028.1; -; Genomic_DNA.
DR EMBL; EU408673; ACB42030.1; -; Genomic_DNA.
DR EMBL; EU408674; ACB42031.1; -; Genomic_DNA.
DR EMBL; EU408677; ACB42034.1; -; Genomic_DNA.
DR EMBL; EU408679; ACB42036.1; -; Genomic_DNA.
DR EMBL; EU408680; ACB42037.1; -; Genomic_DNA.
DR AlphaFoldDB; B9U101; -.
DR VEuPathDB; FungiDB:CGB_M1140W; -.
DR VEuPathDB; FungiDB:CNBG_4798; -.
DR VEuPathDB; FungiDB:I306_04069; -.
DR VEuPathDB; FungiDB:I311_01076; -.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF33; LYSOPHOSPHOLIPASE 1-RELATED; 1.
DR Pfam; PF01735; PLA2_B; 1.
DR SMART; SM00022; PLAc; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51210; PLA2C; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963, ECO:0000256|PROSITE-
KW ProRule:PRU00555};
KW Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103}.
FT DOMAIN 32..555
FT /note="PLA2c"
FT /evidence="ECO:0000259|PROSITE:PS51210"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACB42025.1"
FT NON_TER 577
FT /evidence="ECO:0000313|EMBL:ACB42025.1"
SQ SEQUENCE 577 AA; 62873 MW; 810F7C49DFE8EF62 CRC64;
VTALAIPPET PRIELQAERG LGDKSYAPWQ VDCPTNVTWI RNATSGLGSG ERAYIEAREK
LVQPAIEDMM AARGLETPPR TPVIGVALAG GGYRAMLTGL GGIMSMMNES TEASESETGG
WLEGVSYWSG LSGGSWATGT FMSNGGQLPT SLLENLWNID SNLIFPDDDK VSFYTELYTE
TNAKSDLGFP TQITDLWGLA IGSHVLPEQY QLSNNPNLTF SSLPSVVAAL GNASLPMPII
IAAEREAGEL IIAENATVWE FTPYEFGSWA FGSQYKSPGA FTPIEYLGTS VNDGSPNGTC
WKGFDQLSFV MGTSATLFNG AFLELNGTDS GLLTSLITAF LAELGEDQAD ISRIPNTFSN
YNSGENPIYN LTYITLVDAG ETNQNVPLEP LLVPARVVDA IVAFDASYDT DYIWPNGTAL
RTTYERARVL AEHENTRVLM PEVPSMNGFV NGGYNSRPTF FGCNDTTTPL IIYVPSYPWS
FAANTSTYQL SYETDEANQI LLNGMRSLTL NHSVPTWPTC FACALTDRSF MYTSENRSTT
CQECFDTWCW AGDDNTTQPA KYEPVINSVP PWLIANN
//
