ID B9UED2_9HIV1 Unreviewed; 302 AA.
AC B9UED2;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ACF37624.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ACF37624.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ACF37624.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACF37624.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=382-42 {ECO:0000313|EMBL:ACF37624.1};
RX PubMed=18931623; DOI=10.1097/QAI.0b013e31818a6561;
RA Brennan C.A., Bodelle P., Coffey R., Devare S.G., Golden A., Hackett J.Jr.,
RA Harris B., Holzmayer V., Luk K.C., Schochetman G., Swanson P.,
RA Yamaguchi J., Vallari A., Ndembi N., Ngansop C., Makamche F., Mbanya D.,
RA Gurtler L.G., Zekeng L., Kaptue L.;
RT "The Prevalence of Diverse HIV-1 Strains Was Stable in Cameroonian Blood
RT Donors From 1996 to 2004.";
RL J. Acquir. Immune Defic. Syndr. 0:0-0(2008).
RN [2] {ECO:0000313|EMBL:ACF37624.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=382-42 {ECO:0000313|EMBL:ACF37624.1};
RA Brennan C.;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; EU618165; ACF37624.1; -; Genomic_RNA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR InterPro; IPR001037; Integrase_C_retrovir.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00552; IN_DBD_C; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR Pfam; PF00665; rve; 1.
DR SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS51027; INTEGRASE_DBD; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 4: Predicted;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00450}.
FT DOMAIN 17..58
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 68..218
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 237..284
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS51027"
FT DNA_BIND 237..284
FT /note="Integrase-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACF37624.1"
SQ SEQUENCE 302 AA; 33762 MW; EA16F50F03836684 CRC64;
QVDKLVSNGI RRVLFLDGID KAQXDHEXYH SNWRAMASDF NLPPIVAKEI VASCDKCQLK
GEAMHGQVDC SPGIWQLDCT HLEGKIIIVA VHVASGYIEA EVIPAETGQE TAYFILKLAG
RWPVKVIHTD NGSNFTSAAV KAACWWANVT QEFGIPYNPQ SQGVVESMNK ELKKIIGQVR
DQAEHLKTAV QMAVFIHNFK RKGGIGGYSA GERIIDIIAS DXQTKELQKQ ITKIQXFRVY
YRDSRDPIWK GPAKLLWKGE GAVVIQDNSD IKVVPRRKVK IIRDYGKQMA GDDCVASRQE
ED
//
