ID B9UEX7_9HIV1 Unreviewed; 288 AA.
AC B9UEX7;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ACF37819.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ACF37819.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ACF37819.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACF37819.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A1188 {ECO:0000313|EMBL:ACF37819.1};
RX PubMed=18931623; DOI=10.1097/QAI.0b013e31818a6561;
RA Brennan C.A., Bodelle P., Coffey R., Devare S.G., Golden A., Hackett J.Jr.,
RA Harris B., Holzmayer V., Luk K.C., Schochetman G., Swanson P.,
RA Yamaguchi J., Vallari A., Ndembi N., Ngansop C., Makamche F., Mbanya D.,
RA Gurtler L.G., Zekeng L., Kaptue L.;
RT "The Prevalence of Diverse HIV-1 Strains Was Stable in Cameroonian Blood
RT Donors From 1996 to 2004.";
RL J. Acquir. Immune Defic. Syndr. 0:0-0(2008).
RN [2] {ECO:0000313|EMBL:ACF37819.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A1188 {ECO:0000313|EMBL:ACF37819.1};
RA Brennan C.;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; EU618360; ACF37819.1; -; Genomic_RNA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR InterPro; IPR001037; Integrase_C_retrovir.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00552; IN_DBD_C; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR Pfam; PF00665; rve; 1.
DR SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS51027; INTEGRASE_DBD; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 4: Predicted;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00450}.
FT DOMAIN 3..44
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 54..204
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 223..270
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS51027"
FT DNA_BIND 223..270
FT /note="Integrase-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACF37819.1"
FT NON_TER 288
FT /evidence="ECO:0000313|EMBL:ACF37819.1"
SQ SEQUENCE 288 AA; 32293 MW; EEE20EBD417BF3FC CRC64;
FLDGIDKAQE EHERYHSNWR AMANDFNLPP IVAKEIVASC DKCQLKGEAM HGQVDYDPGV
WQLDCTHLEG KIILVAVHVA SGYIEAEVIP AETGQETAYF ILKLAGRWPV KVIHTDNGSN
FTSAAVKAAC WWANVTQEFG IPYNPQSQGV VESMNKELKK IIGQVRDQAE HLKTAVQMAV
FIHNFKRKGG IGGYSAGERI IDIIATDIQT KELQKQISKI QNFRVYYRDS RDPIWKGPAK
LLWKGEGAVV IQDNSDIKVV PRRKAKIIRD YGKQMAGDDC VAGRQDEN
//
