ID B9WD27_CANDC Unreviewed; 403 AA.
AC B9WD27;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 74.
DE RecName: Full=Pre-mRNA-splicing factor PRP46 {ECO:0000256|ARBA:ARBA00026147, ECO:0000256|RuleBase:RU369036};
DE AltName: Full=Pre-mRNA-processing protein 46 {ECO:0000256|ARBA:ARBA00033071, ECO:0000256|RuleBase:RU369036};
GN OrderedLocusNames=Cd36_80460 {ECO:0000313|CGD:CAL0000168251};
GN ORFNames=CD36_80460 {ECO:0000313|EMBL:CAX42576.1};
OS Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS NRRL Y-17841) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=573826 {ECO:0000313|EMBL:CAX42576.1, ECO:0000313|Proteomes:UP000002605};
RN [1] {ECO:0000313|EMBL:CAX42576.1, ECO:0000313|Proteomes:UP000002605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841
RC {ECO:0000313|Proteomes:UP000002605};
RX PubMed=19745113; DOI=10.1101/gr.097501.109;
RA Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT Candida albicans.";
RL Genome Res. 19:2231-2244(2009).
CC -!- FUNCTION: Involved in pre-mRNA splicing and required for cell cycle
CC progression at G2/M. {ECO:0000256|RuleBase:RU369036}.
CC -!- SUBUNIT: Associated with the spliceosome.
CC {ECO:0000256|RuleBase:RU369036}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369036}.
CC -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family.
CC {ECO:0000256|ARBA:ARBA00025726, ECO:0000256|RuleBase:RU369036}.
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DR EMBL; FM992690; CAX42576.1; -; Genomic_DNA.
DR RefSeq; XP_002418994.1; XM_002418949.1.
DR AlphaFoldDB; B9WD27; -.
DR GeneID; 8046776; -.
DR KEGG; cdu:CD36_80460; -.
DR CGD; CAL0000168251; Cd36_80460.
DR VEuPathDB; FungiDB:CD36_80460; -.
DR eggNOG; KOG0285; Eukaryota.
DR HOGENOM; CLU_000288_72_0_1; -.
DR OrthoDB; 118158at2759; -.
DR Proteomes; UP000002605; Chromosome 3.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR045241; Prp46/PLRG1-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19923:SF0; PLEIOTROPIC REGULATOR 1; 1.
DR PANTHER; PTHR19923; WD40 REPEAT PROTEINPRL1/PRL2-RELATED; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|RuleBase:RU369036};
KW mRNA splicing {ECO:0000256|RuleBase:RU369036};
KW Nucleus {ECO:0000256|RuleBase:RU369036};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU369036};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728, ECO:0000256|RuleBase:RU369036};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 95..137
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 138..179
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 185..226
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 227..268
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 269..310
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 403 AA; 44988 MW; EBDB2C291FB8A0AC CRC64;
MSVPIKLNLK NYRIMSLTAF SRDILMSTDD SILPPEDTLS EAMYNNVKLD YYFNNLSKSH
EQSSVDDQTN QLIVSSAPKS EESPVLEWKL LRTLAGAHQG WIRAIALDEI TNKWYVTGSA
DSTIKIWDFE NNSLKAVLTG HVLGVRSLCI SKRHPYLFSG GEDKSLRCWD LERSNSDAGC
QIRSYHGHLG GVYTIGLHPE LDVLFSGGKD CVVRVWDIRS RVEAMTLLGH TNDITSIQTD
YSDPQVITSS MDGTIRLWDL RKSKTELLIT NHSKSIRSMK SHPKEATFIS GDSNGEIKQW
LLPKGELLNE FGTSQLSPNQ RDNSRIINSL AINPVTNTLF SGYDDGKLEF YNYASGSLQQ
SGQSPSLAGP EQSAIYASTF DMSGLRLLTC HGDKSIRIWG TSY
//
