ID B9WDB5_CANDC Unreviewed; 1171 AA.
AC B9WDB5;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN OrderedLocusNames=Cd36_81370 {ECO:0000313|CGD:CAL0000170382};
GN ORFNames=CD36_81370 {ECO:0000313|EMBL:CAX42667.1};
OS Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS NRRL Y-17841) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=573826 {ECO:0000313|EMBL:CAX42667.1, ECO:0000313|Proteomes:UP000002605};
RN [1] {ECO:0000313|EMBL:CAX42667.1, ECO:0000313|Proteomes:UP000002605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841
RC {ECO:0000313|Proteomes:UP000002605};
RX PubMed=19745113; DOI=10.1101/gr.097501.109;
RA Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT Candida albicans.";
RL Genome Res. 19:2231-2244(2009).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|RuleBase:RU367072}.
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DR EMBL; FM992690; CAX42667.1; -; Genomic_DNA.
DR RefSeq; XP_002419082.1; XM_002419037.1.
DR AlphaFoldDB; B9WDB5; -.
DR GeneID; 8047024; -.
DR KEGG; cdu:CD36_81370; -.
DR CGD; CAL0000170382; Cd36_81370.
DR VEuPathDB; FungiDB:CD36_81370; -.
DR eggNOG; KOG1967; Eukaryota.
DR HOGENOM; CLU_005943_1_0_1; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000002605; Chromosome 3.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 47..324
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 614..1128
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1171 AA; 135023 MW; 15F53EC99D435D2A CRC64;
MVEHNIPILI NQYIAASSGN DEEAVSNYIF ELSNLITNDE LSLLQFIQHL GPSLTSDKDL
IRSKSIECLS KTIISLSDSK LTKQDINVLM EFLLNKLIDN DQICLQYSLM GINSLICKKN
FLADTNIEKI LQNLYKNYDP KKNLAKIRFE TFQILLNLLN QFNQYLKSSI QLTNLYIKTF
IHIASGEKDP RNLLLSFELN SKINENFQFL VDNNELHQQF ITDLFDICFC YFPISFKPPS
NDPYKITSEQ LKVALRKTIA SQSKFASEAF PNLIEKLTST NPTIRNDTLK TLQLCIENYS
NNDPTIIEQY WMTIWNALKF EILHNDIRSN FNPTNNTIVA LDYDEIDDND EFKPLVLTLV
ILNQLIMKLP QPEIMLHTVV EELKPNLEII KEKSIKSSLI LSSLGSTSIE NLNYIVDFLF
QYQVWGKFLN IDKKEEPNQK QEIDTNDDIS LNIAKQRDLI DSIGFVLTAY QVLKPTTTNC
HLLDYKDYIL IFLGQLLNIT SNLEKTLKCK IIQQLIKLIK LPGFLNINEL ELILGNYFKD
FFLLGTTTTT SSSSSSAGKK KDVILQEIIN GLIEVSQDSQ ITSMTIEFII NPILNQLLNN
DDTEIDIETF QFQLEIVGDL CINYQILEVI SIRLLNKLSL IINNQSNDNL QLYKLIINLF
IESIKKIESI QQFLTNSWYK HFIPKFMENL LIILPVKKSF FDDNDYKSDN YELFEIVGDL
LGLIIKFIDV SKHQEILDQL NQAFITNNDQ TNENYGLGPF KYPSNLLIEP TNYINIYNKI
LSSIDKSCVF KTNIDQQVIE LVINLIYKIG SKDEYLRLQY LQTLCLLINK FIKNVDIDII
ESILKLKLLE EFNHKEFPIT EKDFISFEIF IWILKGLIIK LDKLGINYLN QLLELFVITK
NYKFKQLIGK SLQILFIDLK IFTNEKITST TTTTTTTTTT TNSVDTSSND LKSSNQLISK
VKNLQIKSLY KQHIFVIILP YLINNDDSNN FGTDNDFNLK FNSLSLIIEN LSINGNNNIL
INQLSEILPI TLYSLIKIPI DSNSNSNLLA SLIILNIILK EEEKEEKEKE KDINNTNLSL
LTKDNIIELI PILIKLITTT TTNRKSKSKS NSSNIDIKIL SLKNLKLIIE KFDDIINKSK
LLNDLLPGLD DKKRVVRKLT IDLRQLLYDS K
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