ID B9WF76_CANDC Unreviewed; 665 AA.
AC B9WF76;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=Chromatin modification-related protein EAF1 {ECO:0000256|ARBA:ARBA00018561};
DE AltName: Full=ESA1-associated factor 1 {ECO:0000256|ARBA:ARBA00032084};
DE AltName: Full=Vacuolar import and degradation protein 21 {ECO:0000256|ARBA:ARBA00029670};
GN OrderedLocusNames=Cd36_46690 {ECO:0000313|CGD:CAL0000164982};
GN ORFNames=CD36_46690 {ECO:0000313|EMBL:CAX42532.1};
OS Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS NRRL Y-17841) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=573826 {ECO:0000313|EMBL:CAX42532.1, ECO:0000313|Proteomes:UP000002605};
RN [1] {ECO:0000313|EMBL:CAX42532.1, ECO:0000313|Proteomes:UP000002605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841
RC {ECO:0000313|Proteomes:UP000002605};
RX PubMed=19745113; DOI=10.1101/gr.097501.109;
RA Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT Candida albicans.";
RL Genome Res. 19:2231-2244(2009).
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. {ECO:0000256|ARBA:ARBA00025178}.
CC -!- SIMILARITY: Belongs to the EAF1 family.
CC {ECO:0000256|ARBA:ARBA00008913}.
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DR EMBL; FM992691; CAX42532.1; -; Genomic_DNA.
DR RefSeq; XP_002420308.1; XM_002420263.1.
DR AlphaFoldDB; B9WF76; -.
DR GeneID; 8047815; -.
DR KEGG; cdu:CD36_46690; -.
DR CGD; CAL0000164982; Cd36_46690.
DR eggNOG; ENOG502RGMX; Eukaryota.
DR HOGENOM; CLU_006174_1_0_1; -.
DR OrthoDB; 1334563at2759; -.
DR Proteomes; UP000002605; Chromosome 4.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:UniProt.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR46459:SF1; E1A-BINDING PROTEIN P400; 1.
DR PANTHER; PTHR46459; E1A-BINDING PROTEIN P400-RELATED; 1.
DR Pfam; PF07529; HSA; 1.
DR Pfam; PF13921; Myb_DNA-bind_6; 1.
DR SMART; SM00573; HSA; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51204; HSA; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 207..286
FT /note="HSA"
FT /evidence="ECO:0000259|PROSITE:PS51204"
FT DOMAIN 367..425
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT REGION 70..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..620
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 77089 MW; D56849B4EECAE6F1 CRC64;
MSNTWKSRLT EISHITADPF LRDFQKLHTE NPNQILSLLH DSDTFVEHTF KTTIIKSMEE
SMYRPLIPTT EMKRRQATHT EAPPRKVQKT TPYKPTAVKS LKTQDQINQE RLTHYLNQPL
EDLEVMTVPD HYPTSVPVVS SLPELYYLTQ TLPSIKLLPK SHKVLMTENF ESALAEGKIA
VLYSRIEELK RQGKWSLRQP QKFYDPFKFI RKSKKKSAHW DYLLQEGKWM ADDFRESSKY
KKWCCVLIAE AVEEYWKKVA KTPPKPVVDV TNLKKIDNSI IRNLPVYTGL ENDTTKDQPI
ATVSKLIYPS ENDHWYKIVL KQHDHVNSPH TNEPGLFGPQ AHRKYNILKP PKPPPPKNIE
FRIPTIWLPE DDKRLIHYVA EFCFNWDLIS EHISSTSSAV SLKKYESNIE RRTPWQCFER
YIQLNDKFQF SDMKGVYAYH AQQWLEQAHR AQSTTKRRIS PLGVAPESIQ RGNRKLRWAS
MFDAIRKSMK KREIVAAKLN HRKSTAELQA SQNPTSPQST TVPTPAELSR LKFERDKSLH
ENQINHQATR ARMMQAVAPP QQPKRPTTPN GTPLTNEQIQ QLLQMQKHRR MLQLQQQRAN
PAPPLPPPPQ PQPQPPKIHF PPAQVSKVIN DIQQQNPGLS KDQVTKLAAQ YLASLSQGYR
SPNNA
//
