ID B9WFE0_CANDC Unreviewed; 739 AA.
AC B9WFE0;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Outward-rectifier potassium channel, putative {ECO:0000313|EMBL:CAX41959.1};
GN Name=TOK1 {ECO:0000313|EMBL:CAX41959.1};
GN OrderedLocusNames=Cd36_40720 {ECO:0000313|CGD:CAL0000170829};
GN ORFNames=CD36_40720 {ECO:0000313|EMBL:CAX41959.1};
OS Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS NRRL Y-17841) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=573826 {ECO:0000313|EMBL:CAX41959.1, ECO:0000313|Proteomes:UP000002605};
RN [1] {ECO:0000313|EMBL:CAX41959.1, ECO:0000313|Proteomes:UP000002605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841
RC {ECO:0000313|Proteomes:UP000002605};
RX PubMed=19745113; DOI=10.1101/gr.097501.109;
RA Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT Candida albicans.";
RL Genome Res. 19:2231-2244(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|RuleBase:RU003857}.
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DR EMBL; FM992691; CAX41959.1; -; Genomic_DNA.
DR RefSeq; XP_002419744.1; XM_002419699.1.
DR AlphaFoldDB; B9WFE0; -.
DR GeneID; 8047348; -.
DR KEGG; cdu:CD36_40720; -.
DR CGD; CAL0000170829; Cd36_40720.
DR VEuPathDB; FungiDB:CD36_40720; -.
DR eggNOG; KOG1418; Eukaryota.
DR HOGENOM; CLU_013394_2_0_1; -.
DR OrthoDB; 5010334at2759; -.
DR Proteomes; UP000002605; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF291; POTASSIUM CHANNEL SUBFAMILY K MEMBER 18; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|RuleBase:RU003857, ECO:0000313|EMBL:CAX41959.1};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 112..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 285..352
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 415..486
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 519..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 366..393
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 534..555
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 83229 MW; E3B7935C734D2B3D CRC64;
MGFRAPMNGL AKNSKSSAFA SFDSVSVMHI VNKAKDKIVP DPQFHKSITD QGIRHYQEKL
SPLFQNSYHG VSSNTNEQDS PYMKSPVTLQ HALNVRLESI LNLNVRPGEP YFVLWFLISS
YFPLIAACLG PLANMISIVA LVEHWKLDII TNKKVPDIPK VVVMNAISLA LGLIGNVSLL
MNFSRSVKYL VSQSVSIIAW LCASALLAAA LLVTNREFGG ENPKYVPSEG FYFAAFTSGN
YFVCMLILVI NFMGFSLKKY PPTFNLDQKQ RTLMLFTILF SSWTIIGAFT MGSLIDDISY
GSALYYCIVS FLTIGLGDIL PKTSGAKVAV LVFSLGGVLI MGLIVATLRS VILSSAAPAI
FWNDVEKART ALLAQLEREN RELTSEESFH EMRVLRRKVK SRHKKVSLVL TITVFMIFWL
IGALIFQRIE KWSYFNAMYF CFLCLITIGY GDYAPKTSLG RVFFVSWAVG AVPLMTILVS
NVGDALYDIF NDISAWFSTW MFSTKEEYTD LKRRKKRLQE DQEDQLTVNS EAVRSSELDE
DLDLAKMERE ASLEASDGDS NGNIRTVSNN EEDISNEDND TCITNASGSN MQQDKENNSC
SERSVSKSGK QDFNIERIRQ KIASKKQVHE MLIDYLEKMK PLIGDSIESP NRKYSYKQWK
GAYDGFWLSE SSPLRLPLKE PNYLILKIYF EIEMMLRGLV DKEIEDLKAM TIQDVPNGSS
PSASTDRNIA RTIKFDDDK
//
