ID B9ZZE7_ORYLA Unreviewed; 266 AA.
AC B9ZZE7;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Proteasome subunit beta {ECO:0000256|RuleBase:RU004203};
DE Flags: Fragment;
GN Name=PSMB10 {ECO:0000313|EMBL:BAH29622.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|EMBL:BAH29622.1};
RN [1] {ECO:0000313|EMBL:BAH29622.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19126869; DOI=10.1093/molbev/msn305;
RA Tsukamoto K., Sakaizumi M., Hata M., Sawara Y., Eah J., Kim C., Nonaka M.;
RT "Dichotomous haplotypic lineages of the immunoproteasome subunit genes,
RT PSMB8 and PSMB10, in the MHC class I region of a Teleost Medaka, Oryzias
RT latipes.";
RL Mol. Biol. Evol. 26:769-781(2009).
CC -!- FUNCTION: Component of the proteasome, a multicatalytic proteinase
CC complex which is characterized by its ability to cleave peptides with
CC Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or
CC slightly basic pH. The proteasome has an ATP-dependent proteolytic
CC activity. {ECO:0000256|RuleBase:RU004203}.
CC -!- FUNCTION: The proteasome is a multicatalytic proteinase complex which
CC is characterized by its ability to cleave peptides with Arg, Phe, Tyr,
CC Leu, and Glu adjacent to the leaving group at neutral or slightly basic
CC pH. The proteasome has an ATP-dependent proteolytic activity. This
CC subunit is involved in antigen processing to generate class I binding
CC peptides. {ECO:0000256|ARBA:ARBA00025456}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of peptide bonds with very broad specificity.;
CC EC=3.4.25.1; Evidence={ECO:0000256|ARBA:ARBA00001198};
CC -!- SUBUNIT: Component of the proteasome complex.
CC {ECO:0000256|RuleBase:RU004203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU004203}.
CC Nucleus {ECO:0000256|RuleBase:RU004203}.
CC -!- SIMILARITY: Belongs to the peptidase T1B family.
CC {ECO:0000256|RuleBase:RU004203}.
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DR EMBL; AB449610; BAH29622.1; -; Genomic_DNA.
DR EMBL; AB449615; BAH29632.1; -; Genomic_DNA.
DR EMBL; AB449620; BAH29642.1; -; Genomic_DNA.
DR EMBL; AB449637; BAH29676.1; -; Genomic_DNA.
DR EMBL; AB449645; BAH29692.1; -; Genomic_DNA.
DR AlphaFoldDB; B9ZZE7; -.
DR MEROPS; T01.A02; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005839; C:proteasome core complex; IEA:InterPro.
DR GO; GO:0004298; F:threonine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IEA:InterPro.
DR CDD; cd03763; proteasome_beta_type_7; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR000243; Pept_T1A_subB.
DR InterPro; IPR024689; Proteasome_bsu_C.
DR InterPro; IPR016050; Proteasome_bsu_CS.
DR InterPro; IPR001353; Proteasome_sua/b.
DR InterPro; IPR023333; Proteasome_suB-type.
DR PANTHER; PTHR32194; METALLOPROTEASE TLDD; 1.
DR PANTHER; PTHR32194:SF4; PROTEASOME SUBUNIT BETA TYPE-7; 1.
DR Pfam; PF12465; Pr_beta_C; 1.
DR Pfam; PF00227; Proteasome; 1.
DR PRINTS; PR00141; PROTEASOME.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR PROSITE; PS00854; PROTEASOME_BETA_1; 1.
DR PROSITE; PS51476; PROTEASOME_BETA_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU004203};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004203};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|RuleBase:RU004203}.
FT DOMAIN 229..260
FT /note="Proteasome beta subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12465"
FT ACT_SITE 33
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR600243-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAH29622.1"
SQ SEQUENCE 266 AA; 28718 MW; 26B0239449CD3ACE CRC64;
PAAGFNFDNA ARNAAFEGLF EGGQTPKPLK TGTTIAGVVF KDGVVLGADT RATSSEVVAD
KMCAKIHYIS PNIYCCGAGT AADTEKTTDL LSSNLTVFSL NSGRNPRVVM AVNILQDMLY
RYHGQIGANL ILGGVDCTGN HLYTVGPYGS VNKVPYLAMG SGDLAALGIL EDGFQHDLEL
EKAKKLVRDA VHSGIMNDLG SGNNIDICVI TAEGVDYIRP FQESEFKDRR EIKYKYRQGT
TPVLTKKITP LKMEVVQETT QKMETV
//
