ID BIN3D_CAEEL Reviewed; 378 AA.
AC Q9U2R0; Q9XXH6;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE RecName: Full=Probable RNA methyltransferase Y17G7B.18;
DE EC=2.1.1.-;
GN ORFNames=Y17G7B.18;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Probable RNA methyltransferase. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q9U2R0-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q9U2R0-2; Sequence=VSP_025998;
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000305}.
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DR EMBL; AL023828; CAA19465.1; -; Genomic_DNA.
DR EMBL; AL023828; CAA19466.1; -; Genomic_DNA.
DR PIR; T26511; T26511.
DR PIR; T26512; T26512.
DR RefSeq; NP_496572.1; NM_064171.5.
DR RefSeq; NP_496573.1; NM_064172.3. [Q9U2R0-1]
DR AlphaFoldDB; Q9U2R0; -.
DR SMR; Q9U2R0; -.
DR BioGRID; 40153; 1.
DR STRING; 6239.Y17G7B.18b.1; -.
DR EPD; Q9U2R0; -.
DR PaxDb; 6239-Y17G7B-18b; -.
DR PeptideAtlas; Q9U2R0; -.
DR EnsemblMetazoa; Y17G7B.18a.1; Y17G7B.18a.1; WBGene00012469. [Q9U2R0-1]
DR EnsemblMetazoa; Y17G7B.18b.1; Y17G7B.18b.1; WBGene00012469. [Q9U2R0-2]
DR GeneID; 174850; -.
DR KEGG; cel:CELE_Y17G7B.18; -.
DR UCSC; Y17G7B.18a; c. elegans. [Q9U2R0-1]
DR AGR; WB:WBGene00012469; -.
DR WormBase; Y17G7B.18a; CE19052; WBGene00012469; -. [Q9U2R0-1]
DR WormBase; Y17G7B.18b; CE19053; WBGene00012469; -. [Q9U2R0-2]
DR eggNOG; KOG2899; Eukaryota.
DR GeneTree; ENSGT00940000153993; -.
DR InParanoid; Q9U2R0; -.
DR OMA; KNQESFP; -.
DR PhylomeDB; Q9U2R0; -.
DR PRO; PR:Q9U2R0; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00012469; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0008171; F:O-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0008173; F:RNA methyltransferase activity; IBA:GO_Central.
DR GO; GO:0017069; F:snRNA binding; IBA:GO_Central.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0040031; P:snRNA modification; IBA:GO_Central.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR039772; Bin3-like.
DR InterPro; IPR010675; Bin3_C.
DR InterPro; IPR024160; BIN3_SAM-bd_dom.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12315:SF0; 7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME; 1.
DR PANTHER; PTHR12315; BICOID-INTERACTING PROTEIN RELATED; 1.
DR Pfam; PF06859; Bin3; 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51515; BIN3_SAM; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Methyltransferase; Reference proteome;
KW S-adenosyl-L-methionine; Transferase.
FT CHAIN 1..378
FT /note="Probable RNA methyltransferase Y17G7B.18"
FT /id="PRO_0000289268"
FT DOMAIN 136..367
FT /note="Bin3-type SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00848"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 78
FT /note="K -> KKLQ (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_025998"
SQ SEQUENCE 378 AA; 44113 MW; 7F9FB4278BEA02DE CRC64;
MSSHRRGSFR GRKRFYRDTF APGGSKTDPL NIEIELTENP EEEKKRLGLL DPTTERSKKR
KVEKDEKSEK PAENSPFKKN QYNSPRKDSR RPPQLSKEEK SAAENRKQKT EYFNKKYRYG
NFDRYYGIRL NPGESDKRLS VFQKDWFEHK QALDIGCNAG FLTLSIAKDF SPRRIIGIDI
DEHLIGVARK NIRHYCDHET EVSGKFPASF GVQFGTVSQR NEAPRSFSTK FPDNIWFKKE
NYVLESDEML DMIQPEFDVI LALSITKWIH LNWGDDGMRR FFRRAYAQLH PGGRLIIEPQ
AFDSYKKRAK MSEELKANYS KIEFKPEDFE MWLIETVGFE SVEKLGVVGA KSKGFERPID
VYLKPLHPKT DAIPLGYI
//
