ID BOPE_BURP0 Reviewed; 261 AA.
AC A3P6Z0;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Guanine nucleotide exchange factor BopE;
DE AltName: Full=Effector protein BopE;
GN Name=bopE; OrderedLocusNames=BURPS1106A_A2067;
OS Burkholderia pseudomallei (strain 1106a).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=357348;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1106a;
RX PubMed=20333227; DOI=10.1093/gbe/evq003;
RA Losada L., Ronning C.M., DeShazer D., Woods D., Fedorova N., Kim H.S.,
RA Shabalina S.A., Pearson T.R., Brinkac L., Tan P., Nandi T., Crabtree J.,
RA Badger J., Beckstrom-Sternberg S., Saqib M., Schutzer S.E., Keim P.,
RA Nierman W.C.;
RT "Continuing evolution of Burkholderia mallei through genome reduction and
RT large-scale rearrangements.";
RL Genome Biol. Evol. 2:102-116(2010).
CC -!- FUNCTION: Activator for both CDC42 and RAC1 by directly interacting
CC with these Rho GTPases and acting as a guanine nucleotide exchange
CC factor (GEF). This activation results in actin cytoskeleton
CC rearrangements and stimulates membrane ruffling, thus promoting
CC bacterial entry into non-phagocytic cells (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Monomer. Interacts with human CDC42 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted via the bsa
CC type III secretion system. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GEF (guanine exchange factor) SopE family.
CC {ECO:0000305}.
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DR EMBL; CP000573; ABN95087.1; -; Genomic_DNA.
DR RefSeq; WP_004188462.1; NC_009078.1.
DR AlphaFoldDB; A3P6Z0; -.
DR BMRB; A3P6Z0; -.
DR SMR; A3P6Z0; -.
DR GeneID; 56597870; -.
DR KEGG; bpl:BURPS1106A_A2067; -.
DR HOGENOM; CLU_1064256_0_0_4; -.
DR Proteomes; UP000006738; Chromosome II.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.10.4120.10; SopE-like, GEF domain; 1.
DR InterPro; IPR005414; SopE.
DR InterPro; IPR035949; SopE-like_GEF_dom_sf.
DR InterPro; IPR016019; SopE_GEF_dom.
DR Pfam; PF07487; SopE_GEF; 1.
DR PIRSF; PIRSF034781; SecIII_sopE; 1.
DR PRINTS; PR01593; SOPEPROTEIN.
DR SUPFAM; SSF81832; SopE-like GEF domain; 1.
PE 3: Inferred from homology;
KW GTPase activation; Guanine-nucleotide releasing factor; Secreted;
KW Virulence.
FT CHAIN 1..261
FT /note="Guanine nucleotide exchange factor BopE"
FT /id="PRO_0000344031"
SQ SEQUENCE 261 AA; 28735 MW; B54EBF0C5A687D51 CRC64;
MTYNPRIGGF THVKQASFDV HVKRGEAQPR TSFAQQIKRI FSKIGETLGQ LFRHRAPDSA
PGRVRLQGVR YVGSYRPTGD AKQAIRHFVD EAVKQVAHTR TPEIRQDAEF GRQVYEATLC
AIFSEAKDRF CMDPATRAGN VRPAFIEALG DAARATGLPG ADKQGVFTPS GAGTNPLYTE
IRLRADTLMG AELAARPEYR ELQPYARQQA IDLVANALPA ERSNTLVEFR QTVQTLEATY
RRAAQDASRD EKGATNAADG A
//
