ID BXRB_AGRCO Reviewed; 93 AA.
AC O09210;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 22-FEB-2023, entry version 86.
DE RecName: Full=Bombyxin-related peptide B;
DE AltName: Full=ABRP;
DE Contains:
DE RecName: Full=Bombyxin-related peptide B chain B;
DE Contains:
DE RecName: Full=Bombyxin-related peptide B chain A;
DE Flags: Precursor;
OS Agrius convolvuli (Convolvulus hawk-moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Sphingidae; Sphinginae; Acherontiini; Agrius.
OX NCBI_TaxID=55055 {ECO:0000312|EMBL:BAA20092.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Brain {ECO:0000269|PubMed:8673077};
RX PubMed=8673077; DOI=10.1016/0965-1748(95)00057-7;
RA Iwami M., Furuya I., Kataoka H.;
RT "Bombyxin-related peptides: cDNA structure and expression in the brain of
RT the hornworm Agrius convolvuli.";
RL Insect Biochem. Mol. Biol. 26:25-32(1996).
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|RuleBase:RU000406,
CC ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Located in 4 pairs of medial neurosecretory cells
CC in the brain. {ECO:0000269|PubMed:8673077}.
CC -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR EMBL; D63148; BAA20092.1; -; mRNA.
DR AlphaFoldDB; O09210; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0018445; F:prothoracicotrophic hormone activity; NAS:UniProtKB.
DR CDD; cd04366; IlGF_insulin_bombyxin_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR017097; Bombyxin.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46886; INSULIN-LIKE GROWTH FACTOR II; 1.
DR PANTHER; PTHR46886:SF1; INSULIN-LIKE GROWTH FACTOR II; 1.
DR Pfam; PF00049; Insulin; 1.
DR PIRSF; PIRSF037038; Bombyxin; 1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Hormone; Secreted;
KW Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PEPTIDE 22..44
FT /note="Bombyxin-related peptide B chain B"
FT /id="PRO_0000015959"
FT PROPEP 47..71
FT /note="C peptide like"
FT /id="PRO_0000015960"
FT PEPTIDE 74..93
FT /note="Bombyxin-related peptide B chain A"
FT /id="PRO_0000015961"
FT DISULFID 25..80
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250"
FT DISULFID 37..93
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250"
FT DISULFID 79..84
FT /evidence="ECO:0000250"
SQ SEQUENCE 93 AA; 10077 MW; 15BDE6781B68A3B3 CRC64;
MKFVLVLVSL ALLVSLASVQ GNNYCGRHLS ETLAYMCPEL EGASKRSGAM GAAAMYGTRG
WRWAAMGGNR GKRGVVEECC YQSCTLDELL TYC
//
