ID C0BLZ6_9BACT Unreviewed; 314 AA.
AC C0BLZ6;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 13-SEP-2023, entry version 50.
DE RecName: Full=dTDP-4-dehydrorhamnose reductase {ECO:0000256|RuleBase:RU364082};
DE EC=1.1.1.133 {ECO:0000256|RuleBase:RU364082};
GN ORFNames=Flav3CDRAFT_1257 {ECO:0000313|EMBL:EEG43779.1};
OS Flavobacteria bacterium MS024-3C.
OC Bacteria; Bacteroidota; Flavobacteriia.
OX NCBI_TaxID=487797 {ECO:0000313|EMBL:EEG43779.1, ECO:0000313|Proteomes:UP000003631};
RN [1] {ECO:0000313|EMBL:EEG43779.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS024-3C {ECO:0000313|EMBL:EEG43779.1};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Woyke T., Xie G., Copeland A., Gonzalez J., Han C., Kiss H., Saw J.,
RA Senin P., Chatterji S., Cheng J.-F., Eisen J.A., Sieracki M.E.,
RA Stepanauskas R.;
RT "Assembling the metagenome, one cell at a time.";
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to
CC yield dTDP-L-rhamnose. {ECO:0000256|RuleBase:RU364082}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-
CC rhamnose + H(+) + NADPH; Xref=Rhea:RHEA:21796, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57510, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:62830; EC=1.1.1.133;
CC Evidence={ECO:0000256|RuleBase:RU364082};
CC -!- PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.
CC {ECO:0000256|RuleBase:RU364082}.
CC -!- SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose reductase family.
CC {ECO:0000256|ARBA:ARBA00010944, ECO:0000256|RuleBase:RU364082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEG43779.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABVW01000001; EEG43779.1; -; Genomic_DNA.
DR AlphaFoldDB; C0BLZ6; -.
DR STRING; 487797.Flav3CDRAFT_1257; -.
DR OrthoDB; 9803892at2; -.
DR UniPathway; UPA00124; -.
DR Proteomes; UP000003631; Unassembled WGS sequence.
DR GO; GO:0008831; F:dTDP-4-dehydrorhamnose reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0019305; P:dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05254; dTDP_HR_like_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR005913; dTDP_dehydrorham_reduct.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR029903; RmlD-like-bd.
DR NCBIfam; TIGR01214; rmlD; 1.
DR PANTHER; PTHR10491; DTDP-4-DEHYDRORHAMNOSE REDUCTASE; 1.
DR PANTHER; PTHR10491:SF4; METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA; 1.
DR Pfam; PF04321; RmlD_sub_bind; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|RuleBase:RU364082};
KW Oxidoreductase {ECO:0000256|RuleBase:RU364082,
KW ECO:0000313|EMBL:EEG43779.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003631}.
FT DOMAIN 10..310
FT /note="RmlD-like substrate binding"
FT /evidence="ECO:0000259|Pfam:PF04321"
SQ SEQUENCE 314 AA; 33951 MW; 7EECCC23FB278C31 CRC64;
MSTQSPMYSV LVSGASGQVG QSLRHVLDTE ETPLFSKNSW GFLDRSSLDL SQSDNLSSVI
EGLLDKHAPK AFVHAAAFTA VDAAETQKEA AFTINETATR ILAAACAKRN ILFVYLSTDF
VFAGKSTDQK PFLPSDPIHP IGVYAQSKAA GEKAVQLHGG PHYIVRTSWV FSPFGNNFVK
TMLRLAKERL QFLSEPNQQT SARVKPTISV VSDQFGCPTS ALDLARALLA LITVQSLPYG
ILHFSNAGPV HWAQLAGAVF EQSNLPITVK PISSEDFAAA APRPAYSVLE NTLDPKARHW
KEALAEVLSI LKTA
//
