ID C0H9S6_SALSA Unreviewed; 649 AA.
AC C0H9S6;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Rho guanine nucleotide exchange factor 4 {ECO:0000313|EMBL:ACN10795.1, ECO:0000313|RefSeq:NP_001167091.1};
GN Name=ARHG4 {ECO:0000313|EMBL:ACN10795.1};
GN Synonyms=arhg4 {ECO:0000313|RefSeq:NP_001167091.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACN10795.1};
RN [1] {ECO:0000313|EMBL:ACN10795.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN10795.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACN10795.1, ECO:0000313|RefSeq:NP_001167091.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN10795.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACN10795.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACN10795.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001167091.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BT059082; ACN10795.1; -; mRNA.
DR RefSeq; NP_001167091.1; NM_001173620.1.
DR GeneID; 100380335; -.
DR KEGG; sasa:100380335; -.
DR CTD; 100380335; -.
DR OrthoDB; 4180430at2759; -.
DR Proteomes; UP000087266; Chromosome ssa29.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11973; SH3_ASEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 143..202
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 241..425
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 456..563
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 73544 MW; FB319558514F6453 CRC64;
MRTQQGFEEP VPLPGDSSGS TSSGLSPGSP GSDSDSGTPT EGGGRGVGGG MGEKWGAGGG
GGMGSLGGTL RGVLSHYWSL ESLHSTTAVI VPDGGGEKTG LGLGDDLGSD EDLYEEFRSS
RHHFGHPGGG GEQLAINELI SDGSCVYAEA LWDHVTMDDQ ELGFKAGDVI EVVDATNKEW
WWGRILDSEG WFPASFVRLR VNQDEPMEEY LAQLEEAGAG ENDQPGVGLF LGPGLPCKEQ
MRANVINEIM ITERDYIKHL KDICDGYIKQ CRKRIDMFTE EQLLCIFGNI EDIYRFQKRF
LKGLEKRFNK EQPHLSEIGS CFLEHQTDFQ IYSEYCNNHP NACVQLSRRM KTNKYVFFFE
ACRLLQKMID ISLDGFLLTP VQKICKYPLQ LAELLKYTNP QHRDYKDVEA ALNAMKNVAR
LINERKRRLE NIDKIAQWQR SIEDWEGEDI LSKSSDLIFS GELTKISQPQ AKSQQRMFFL
FDHQMVYCKK DLLRRDMLYY KGRMDMDQME VVDVEDGKEK DFNVSVKNAL KLRSLAGDEV
HLLCAKKPEQ KQRWLRAFQD ERRQVQHDRE TGFSITEVQK KQAMLNACKS HPAGKPKAVT
RPYCDFLLRQ KQPSLPSSVP QQQVFMLAEP KRKATTFWQN IGRLTPFKK
//
