ID C0KDB7_VIBPH Unreviewed; 138 AA.
AC C0KDB7;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=proton-translocating NAD(P)(+) transhydrogenase {ECO:0000256|ARBA:ARBA00012943};
DE EC=7.1.1.1 {ECO:0000256|ARBA:ARBA00012943};
DE Flags: Fragment;
OS Vibrio parahaemolyticus.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=670 {ECO:0000313|EMBL:ACM90240.1};
RN [1] {ECO:0000313|EMBL:ACM90240.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=K4250 {ECO:0000313|EMBL:ACM90240.1};
RX PubMed=19749061; DOI=10.1128/AEM.01171-09;
RA Hazen T.H., Martinez R.J., Chen Y., Lafon P.C., Garrett N.M., Parsons M.B.,
RA Bopp C.A., Sullards M.C., Sobecky P.A.;
RT "Rapid identification of Vibrio parahaemolyticus by whole-cell matrix-
RT assisted laser desorption ionization-time of flight mass spectrometry.";
RL Appl. Environ. Microbiol. 75:6745-6756(2009).
CC -!- FUNCTION: The transhydrogenation between NADH and NADP is coupled to
CC respiration and ATP hydrolysis and functions as a proton pump across
CC the membrane. {ECO:0000256|ARBA:ARBA00003943}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+);
CC Xref=Rhea:RHEA:47992, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349; EC=7.1.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000006};
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DR EMBL; FJ577437; ACM90240.1; -; Genomic_DNA.
DR AlphaFoldDB; C0KDB7; -.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10160; NAD(P) TRANSHYDROGENASE; 1.
DR PANTHER; PTHR10160:SF19; PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE; 1.
DR Pfam; PF01262; AlaDh_PNT_C; 1.
DR SMART; SM01002; AlaDh_PNT_C; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Translocase {ECO:0000256|ARBA:ARBA00022967}.
FT DOMAIN 1..87
FT /note="Alanine dehydrogenase/pyridine nucleotide
FT transhydrogenase NAD(H)-binding"
FT /evidence="ECO:0000259|SMART:SM01002"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACM90240.1"
FT NON_TER 138
FT /evidence="ECO:0000313|EMBL:ACM90240.1"
SQ SEQUENCE 138 AA; 15017 MW; 711F76850B946CF2 CRC64;
GYAKEMSDDF NKKAAELYAE QAKDVDIFIT TALIPGRPAP KLITKEMVDS MKAGSVIVDL
AAANGGNCEY TVKDQVIMTD NGVKIVGYTD MVGRLPTQSS QLYATNLVNL LKLLCKEKDG
NINIDFEDVV LRGVTVIK
//
