ID   C0KGB2_ARALP            Unreviewed;       670 AA.
AC   C0KGB2;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   28-JUN-2023, entry version 53.
DE   SubName: Full=MEDEA {ECO:0000313|EMBL:ACN86194.1};
DE   Flags: Fragment;
GN   Name=MEDEA {ECO:0000313|EMBL:ACN86194.1};
OS   Arabidopsis lyrata subsp. petraea (Northern rock-cress) (Cardaminopsis
OS   petraea).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=59691 {ECO:0000313|EMBL:ACN86194.1};
RN   [1] {ECO:0000313|EMBL:ACN86194.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ExA {ECO:0000313|EMBL:ACN86194.1};
RC   TISSUE=Flower {ECO:0000313|EMBL:ACN86194.1};
RX   PubMed=19126870; DOI=10.1093/molbev/msp001;
RA   Miyake T., Takebayashi N., Wolf D.E.;
RT   "Possible diversifying selection in the imprinted gene, MEDEA, in
RT   Arabidopsis.";
RL   Mol. Biol. Evol. 26:843-857(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC         + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC         COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC         Evidence={ECO:0000256|ARBA:ARBA00000090};
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DR   EMBL; FJ600430; ACN86194.1; -; mRNA.
DR   AlphaFoldDB; C0KGB2; -.
DR   GO; GO:0031519; C:PcG protein complex; IEA:InterPro.
DR   GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd10519; SET_EZH; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR026489; CXC_dom.
DR   InterPro; IPR045318; EZH1/2-like.
DR   InterPro; IPR025778; Hist-Lys_N-MeTrfase_plant.
DR   InterPro; IPR041355; Pre-SET_CXC.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR   PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR   PANTHER; PTHR45747:SF7; HISTONE-LYSINE N-METHYLTRANSFERASE MEDEA; 1.
DR   Pfam; PF18264; preSET_CXC; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM01114; CXC; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51633; CXC; 1.
DR   PROSITE; PS51576; SAM_MT43_EZ; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          409..513
FT                   /note="CXC"
FT                   /evidence="ECO:0000259|PROSITE:PS51633"
FT   DOMAIN          525..640
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          150..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          647..670
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..167
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACN86194.1"
SQ   SEQUENCE   670 AA;  77069 MW;  133DD2479879FB53 CRC64;
     DNHEDDGEDL PPEINQIKEQ IEEERFLHIK KTFELRCIPS VAAHASHHQS FDLNQPLAED
     DNEGDNKTLL SRMQNPLHHF SALSDSDTYE DQRCVFNKEA PLFPSINLPV VEQLPRSLTW
     VFIKSSQLMA ESDSVIGKRQ IYYLNGEALE LSSEEDEEDE EEDEEETKKE KCEFSKDVDR
     FIWTVGQDYG LDDLVVQRAL AKFLEVEVSD ILERYNELKL KNDETVGEAS DMTSKTITTA
     FQDFADRRHC RRCLIFDCHM HEKFEPEFRP TEDKSGLFEN EDRQPCSEHC YLKVRSVTEA
     DHAVDNDNSI SNKNVVSDPN TTMWTPVEKD LYLKGVQIFG RNSCAITLNI LRGLKTCLEV
     YNYMLEQDQC TMSLVLHKTT KTKNQVNKKV SRKGTRSVRK KSRLRKYARY PPALKKTTNG
     EAKFYKHYTP CTCKSKCGYQ CPCLTNENCC EKYCGCPKDC NNRFGGCNCA IGQCTNRQCP
     CFAANRECDP DLCRSCPLSC GDGSLGEPSE QIQCKNMHFL LKKNKKILIG KSNVHGWGAF
     TPDSLKKNEF LGEYTGELIT HEEANERGRV EDRIGSSYLF TLNDQLEIDA RRYGNKFKFL
     NHSARPNCYA KLMIVRGDQR IGLFAERAIE QNEELFFDYC YGPEHADWSR GREPRKTGAS
     KRSKEARPSR
//