ID C0L5D9_9MOLU Unreviewed; 340 AA.
AC C0L5D9;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 08-NOV-2023, entry version 56.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
DE Flags: Fragment;
GN Name=ParE {ECO:0000313|EMBL:ACN62718.1};
OS Spiroplasma endosymbiont of Drosophila hydei.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=375557 {ECO:0000313|EMBL:ACN62718.1};
RN [1] {ECO:0000313|EMBL:ACN62718.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FC706105A {ECO:0000313|EMBL:ACN62730.1}, FC706106A
RC {ECO:0000313|EMBL:ACN62731.1}, FC806113 {ECO:0000313|EMBL:ACN62748.1},
RC FC806115A {ECO:0000313|EMBL:ACN62718.1}, FC806117
RC {ECO:0000313|EMBL:ACN62719.1}, FC806121A
RC {ECO:0000313|EMBL:ACN62720.1}, FC806137 {ECO:0000313|EMBL:ACN62749.1},
RC FC806138 {ECO:0000313|EMBL:ACN62750.1}, JapanMTS117
RC {ECO:0000313|EMBL:ACN62741.1}, Mag1 {ECO:0000313|EMBL:ACN62742.1},
RC Mag11 {ECO:0000313|EMBL:ACN62725.1}, Mag17
RC {ECO:0000313|EMBL:ACN62726.1}, Mag19 {ECO:0000313|EMBL:ACN62727.1},
RC Mag2 {ECO:0000313|EMBL:ACN62743.1}, Mag5
RC {ECO:0000313|EMBL:ACN62744.1}, Mag7 {ECO:0000313|EMBL:ACN62745.1},
RC Mag8 {ECO:0000313|EMBL:ACN62729.1}, Mag9
RC {ECO:0000313|EMBL:ACN62724.1}, Pil19 {ECO:0000313|EMBL:ACN62732.1},
RC Pil5 {ECO:0000313|EMBL:ACN62733.1}, SC307e7
RC {ECO:0000313|EMBL:ACN62722.1}, SC40610 {ECO:0000313|EMBL:ACN62734.1},
RC SC40626 {ECO:0000313|EMBL:ACN62746.1}, SC40630
RC {ECO:0000313|EMBL:ACN62747.1}, SC4064 {ECO:0000313|EMBL:ACN62723.1},
RC SPE123103 {ECO:0000313|EMBL:ACN62740.1}, TEN104102
RC {ECO:0000313|EMBL:ACN62738.1}, TEN104106
RC {ECO:0000313|EMBL:ACN62739.1}, TU60568 {ECO:0000313|EMBL:ACN62735.1},
RC TU705 {ECO:0000313|EMBL:ACN62736.1}, and TU805
RC {ECO:0000313|EMBL:ACN62737.1};
RX PubMed=19226322; DOI=10.1111/j.1365-294X.2009.04085.x;
RA Haselkorn T.S., Markow T.A., Moran N.A.;
RT "Multiple introductions of the Spiroplasma bacterial endosymbiont into
RT Drosophila.";
RL Mol. Ecol. 0:0-0(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
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DR EMBL; FJ657062; ACN62718.1; -; Genomic_DNA.
DR EMBL; FJ657063; ACN62719.1; -; Genomic_DNA.
DR EMBL; FJ657064; ACN62720.1; -; Genomic_DNA.
DR EMBL; FJ657066; ACN62722.1; -; Genomic_DNA.
DR EMBL; FJ657067; ACN62723.1; -; Genomic_DNA.
DR EMBL; FJ657068; ACN62724.1; -; Genomic_DNA.
DR EMBL; FJ657069; ACN62725.1; -; Genomic_DNA.
DR EMBL; FJ657070; ACN62726.1; -; Genomic_DNA.
DR EMBL; FJ657071; ACN62727.1; -; Genomic_DNA.
DR EMBL; FJ657073; ACN62729.1; -; Genomic_DNA.
DR EMBL; FJ657074; ACN62730.1; -; Genomic_DNA.
DR EMBL; FJ657075; ACN62731.1; -; Genomic_DNA.
DR EMBL; FJ657076; ACN62732.1; -; Genomic_DNA.
DR EMBL; FJ657077; ACN62733.1; -; Genomic_DNA.
DR EMBL; FJ657078; ACN62734.1; -; Genomic_DNA.
DR EMBL; FJ657079; ACN62735.1; -; Genomic_DNA.
DR EMBL; FJ657080; ACN62736.1; -; Genomic_DNA.
DR EMBL; FJ657081; ACN62737.1; -; Genomic_DNA.
DR EMBL; FJ657082; ACN62738.1; -; Genomic_DNA.
DR EMBL; FJ657083; ACN62739.1; -; Genomic_DNA.
DR EMBL; FJ657084; ACN62740.1; -; Genomic_DNA.
DR EMBL; FJ657085; ACN62741.1; -; Genomic_DNA.
DR EMBL; FJ657086; ACN62742.1; -; Genomic_DNA.
DR EMBL; FJ657087; ACN62743.1; -; Genomic_DNA.
DR EMBL; FJ657088; ACN62744.1; -; Genomic_DNA.
DR EMBL; FJ657089; ACN62745.1; -; Genomic_DNA.
DR EMBL; FJ657090; ACN62746.1; -; Genomic_DNA.
DR EMBL; FJ657091; ACN62747.1; -; Genomic_DNA.
DR EMBL; FJ657092; ACN62748.1; -; Genomic_DNA.
DR EMBL; FJ657093; ACN62749.1; -; Genomic_DNA.
DR EMBL; FJ657094; ACN62750.1; -; Genomic_DNA.
DR AlphaFoldDB; C0L5D9; -.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR PANTHER; PTHR45866:SF12; DNA TOPOISOMERASE 4 SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ACN62718.1}.
FT DOMAIN 103..273
FT /note="DNA topoisomerase type IIA subunit B"
FT /evidence="ECO:0000259|Pfam:PF00204"
FT REGION 271..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACN62718.1"
FT NON_TER 340
FT /evidence="ECO:0000313|EMBL:ACN62718.1"
SQ SEQUENCE 340 AA; 37874 MW; 95DE94F98A1B806A CRC64;
GSSVVNALSS VFDVKIYRDT KIWHIKFGNG GQVKQPLTEI GTTNETGTTI TFLPDSKIFK
VIDFSFTTIS ERIRESAFLN SGVKITLTDE RADKTVEYLF NNGLEEFITY MNEGKKSITP
IVMMKGLEKE IEVEVALQYS TEFNENLLSF ANNVKTSEGG SHVVGFRSGL TKVINDYARK
EGLLKEKDKN LDSTDTREGL TAIISVKVPE SLIQYEGQTK GKLGTYDARA AVEIIVTKQF
GFWLTENKTS AYAIIEKALL ARNVREEARK AREAARNNKK RGNSDRLLTG KLTPAQNRNK
LNNEIFLVEG DSAGGSAKLG RDRRFQAILP LRGKVINAEK
//
