ID C0NJV7_AJECG Unreviewed; 859 AA.
AC C0NJV7;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=HCBG_03437 {ECO:0000313|EMBL:EEH08148.1};
OS Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS (Darling's disease fungus) (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH08148.1, ECO:0000313|Proteomes:UP000001631};
RN [1] {ECO:0000313|Proteomes:UP000001631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC {ECO:0000313|Proteomes:UP000001631};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; GG663366; EEH08148.1; -; Genomic_DNA.
DR AlphaFoldDB; C0NJV7; -.
DR STRING; 447093.C0NJV7; -.
DR VEuPathDB; FungiDB:I7I50_07044; -.
DR HOGENOM; CLU_005230_0_2_1; -.
DR InParanoid; C0NJV7; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000001631; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000001631};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 427..452
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 473..490
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 551..569
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 581..604
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 643..663
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 762..785
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 791..815
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 101..128
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 859 AA; 97724 MW; D0B62587F1B8B953 CRC64;
MGVPQDTLFR SADMSLTQLY IANEIGREVV SALGEIGQVQ FRDLNPDTTA FQRTFTNEIR
RLDNVDRQLR YFHSQLEKAG IPLRSSSEFS NTLAAPMASE IDELADRSES LEQRVTSLNE
NYEALQKREI ELVEWRWVLR EAGGFFDRAH GHTEEIRQSF ENDEAPLLRD VEQQPARGQN
GDTETQQAFS VMNIGFVAGV IPRDRIAALE RILWRTLRGN LYMNQSEIPE AIIDPSNNEK
IHKNVFVIFA HGKEIIAKIR KISESLGANL YSVDENSELR RDQIHEVNTR VGDVGSFLRN
TKSTLDAELT QIARSLAAWM IIVKKEKATY HTLNKFSYDQ ARKTLIAEAW CPTNSLPLIK
ATLQDVNDRA GLSVPTIVNQ IRTNKTPPTY IKTNRFTEGF QVIINAYGTA KYGEVNPGLP
TIITFPFLFA VMFGDFGHGM LMTMVATGMI LFERKLLKTK VDEITAMAFY GRYIMLMMGI
FSMYTGLIYN DIFSRSMEVF TSAWKWPEHF NKGDALTAEL KSSYRYPFGL DSAWHGTEND
LLFANSFKMK LSVLLGWAHM TYSLCLSYIN GRHFKRPIEI WGNFVPGMIF FQSIFGYLTF
TIIYKWCVDW NARGQTPPGL LNLLIFMFLK PGTVEEKLYP GQGVVQVILL LVAVIQIPIL
LFLKPFYLRW EHNRTRALGY RGLGETARVS ALDGEDNGDS HILGDGRTSL GNDADGIAMI
TQDISEEEHE EFEFSEAMIH QIIHTIEFCL NCVSHTASYL RLWALSLAHQ QLSVVLWTMT
IGGAFSMESN VARVIMIIAT FYMWFTLTFA ILCVMEGTSA MLHSLRLHWV EAMSKHFIGD
GIPFLAFSFK TLLEEEPVD
//
