ID C0NP11_AJECG Unreviewed; 718 AA.
AC C0NP11;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Golgi apyrase {ECO:0000313|EMBL:EEH06671.1};
GN ORFNames=HCBG_04891 {ECO:0000313|EMBL:EEH06671.1};
OS Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS (Darling's disease fungus) (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH06671.1, ECO:0000313|Proteomes:UP000001631};
RN [1] {ECO:0000313|Proteomes:UP000001631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC {ECO:0000313|Proteomes:UP000001631};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR EMBL; GG663368; EEH06671.1; -; Genomic_DNA.
DR AlphaFoldDB; C0NP11; -.
DR STRING; 447093.C0NP11; -.
DR VEuPathDB; FungiDB:I7I50_05000; -.
DR HOGENOM; CLU_010246_3_0_1; -.
DR InParanoid; C0NP11; -.
DR OrthoDB; 180318at2759; -.
DR Proteomes; UP000001631; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017110; F:nucleoside diphosphate phosphatase activity; IEA:UniProt.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF121; NUCLEOSIDE-DIPHOSPHATASE MIG-23; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001631};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 484..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 432..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 91
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 128..132
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 718 AA; 79098 MW; D80639DAB86DC261 CRC64;
MGICISTFAE NPETIGEEHL RPLLDHAQEV IPDEEISDTP VFLLATAGMR LLPKQKQRAI
LDNICAYIRR STNFLIPDCR QHVQVIEGDT EGLYGWIAIN YLMGGFDNSR AHNHGKGHHT
YGFLDMGGAS AQIAFAPNAT ETEKHANDLT LLRLRTLNGL PMEYGVFVTS WLGFGAREAR
SRYVKALLEA TANEKNRARP DPCLHSGLRM AHDGTILPPA GPVPGVEPYL VGIGKFEECY
RNTYPLLEKD APCPEEPCLL HGVHVPAIDF DVNHFIGIFD MGHQDGTYDF NTYIKRVEEF
CSQPWGVVEQ KVDSKQWGNK VDQETACAVC FKASWLISIL HDGIGIPRVS IGNTPPGEQN
GTDRELTQSK EKGYLDAFQA VHKIDSTEVS WTLGIAVLYA SSQVPPLPNG LPVGFGSNPP
VGSKNRIPED FQQPGAPYLI PTPPAPSQSS NTQNNGTAAH PHASGIVSSH WHDTLFNGHS
SHRIPGLFLL IIVFIAIFFL CGRGGRVRLY RRLIKRSSHS PYYNHNHNYY RRRGGGATFS
SKLFNHMLPR IFSSTSLKRT SSFTASYDSL LETGGRDFEP SPSSSPTDDE AMSISLSMSI
PPTLPNTPFT PAFTNTYSDD NNTNNILVRT KSTNSMYHHN HHHNNHNDNN NPCSTSGIGI
GLSNPPGLDT TAIISSLGNM DRRGLAVRTE SRDRLAASTL GQTNNGRRSR AASPVRHH
//
