ID C0NVE9_AJECG Unreviewed; 1373 AA.
AC C0NVE9;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Sterility protein Ste20 {ECO:0000313|EMBL:EEH04488.1};
GN ORFNames=HCBG_07129 {ECO:0000313|EMBL:EEH04488.1};
OS Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS (Darling's disease fungus) (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH04488.1, ECO:0000313|Proteomes:UP000001631};
RN [1] {ECO:0000313|Proteomes:UP000001631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC {ECO:0000313|Proteomes:UP000001631};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RICTOR family.
CC {ECO:0000256|ARBA:ARBA00008878}.
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DR EMBL; GG663373; EEH04488.1; -; Genomic_DNA.
DR AlphaFoldDB; C0NVE9; -.
DR STRING; 447093.C0NVE9; -.
DR VEuPathDB; FungiDB:I7I50_09411; -.
DR HOGENOM; CLU_001013_1_1_1; -.
DR InParanoid; C0NVE9; -.
DR OrthoDB; 90320at2759; -.
DR Proteomes; UP000001631; Unassembled WGS sequence.
DR GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR CDD; cd11627; HR1_Ste20-like; 1.
DR Gene3D; 1.10.287.160; HR1 repeat; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036274; HR1_rpt_sf.
DR InterPro; IPR028268; Pianissimo_fam.
DR InterPro; IPR028267; Pianissimo_N.
DR InterPro; IPR029453; Rictor_IV.
DR InterPro; IPR029451; RICTOR_M.
DR InterPro; IPR029452; RICTOR_V.
DR PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR Pfam; PF02185; HR1; 1.
DR Pfam; PF14663; RasGEF_N_2; 1.
DR Pfam; PF14666; RICTOR_M; 1.
DR Pfam; PF14664; RICTOR_N; 1.
DR Pfam; PF14668; RICTOR_V; 1.
DR SMART; SM00742; Hr1; 1.
DR SMART; SM01303; RasGEF_N_2; 1.
DR SMART; SM01307; RICTOR_M; 1.
DR SMART; SM01308; RICTOR_N; 1.
DR SMART; SM01310; RICTOR_V; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF46585; HR1 repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001631}.
FT DOMAIN 141..210
FT /note="REM-1"
FT /evidence="ECO:0000259|SMART:SM00742"
FT DOMAIN 273..637
FT /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT /evidence="ECO:0000259|SMART:SM01308"
FT DOMAIN 716..940
FT /note="Rapamycin-insensitive companion of mTOR middle"
FT /evidence="ECO:0000259|SMART:SM01307"
FT DOMAIN 1124..1196
FT /note="Rapamycin-insensitive companion of mTOR"
FT /evidence="ECO:0000259|SMART:SM01310"
FT REGION 1..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1373 AA; 152485 MW; E6CAA31198D20E56 CRC64;
MASNYDPASS ATPTQRRVLN DGNPFSSQED ASTDGSWHDA ASKSSGNRIG SNPAPTATSS
NSSSCSSSNN NNSNNINNTN NFGPWSASFA PSGPPPGSFS SDLKSISSTR GPTTSTPRPE
PPFPSRIIAI DGVDVLARAE QRQAVLRGKI AKELKIKSGT ENMLEALLVK NLKQTKEQRL
RVESELSSSN MKLAQLRHEL EEEILRAQAQ TSPTAGRLST LFRGTPLRSP SRASQGGDAG
MGSGDAETES PTYVLAETLQ ELETTDMPSD YYVERANNLV DLFKRHPTLK YDLAWQVFGL
RVQTMLLSDS RDVVAAGYRL TRHAIADRRS IQIIRSFHTD EMVMMSLVKE TKATIEREQA
LKFVRAFLDV KDGVRELSRG VVRTLVSIAD HRDDRLRNIC IMTLAEILVK DPGLLFFAGG
IGVLNDALGE GVYGASESLA AGFIHILDTP RNRIYLRAGC ELEGVFATFT DPLGDSNHHA
RLKSSAKTIS SMLKTWPGLL TLLRNKAKPL QSLLNSLQYP EPLARDLILE LLFDALRIKP
PSWSSSFLAG RRLTTYGRVT NLRSESDTKH LRAFDEHENN SFDLTTHFSA LVLAVLIEAG
LITALSNLIE DEPDLSLKRK GTLLLTEVLK LAHHSLPQSM SAKLQVLPQL LPCSTPRDTE
TYHVSTSTVY QMESINRTLT RSDGMQSSRG KYTVHTDISA SLLTTEQGKT KLSASMDEGQ
FRTAVLDTHV LSSVNFMKWK WDLIHNIIEG PLTNPKRLDE AIRGSKFMKR LMGFYRPFKS
RFSMIRNTKP NQRYVRTGCA LMRTLLQTPE GTKYLAENKL LRQIAECLAQ VDRMSGLTSS
SPVFSRNNMS ETLSGGYFAL LGVLSSEPGG LQMMERWHMH NMFYHIIELK DRNDLIQTLL
GNMDFSLESH LRIILSKALT TGSKDIRIFA TKLLRKYVVG SVSFPAPMVD IGNGEWVVKL
LVTQLYDPEV AVCQVAVKIL EEACNQRSCL EYVVKCRPSL DHLGEIGAPL LLRFLSTSVG
YHYLDGLDYI TQEMDDWFLG RNDAYVGLVE ASLTRAYVDQ PRRNSFAFDD IVEMQDIGLV
PPHFYRELAR THEGCKLLEQ SGHFNEFAHT IRDFRLDEED PEVLLKVKGC LWAVGNVGSM
DLSAPFLEET EIVGAIGKIA ENAGVMTMRG TAFFVLGLIS RSLHGMEMLL EAGWDAAVDQ
KGRSLGSCIP VQLSRLYSVS FPAYEPNIDE ERAEKERFKA AATDSDPVCQ KILDLIIDMG
NTVLSKRAAS DLNTLRTKKP EYFRQIPLFQ KTLILLESHH FRLPARRFAL DLFDRSVLRR
IVRGDWDGDG DGANADIDAY ADIDVDISID GDGDIDGVPA SNLQPDADTS MGN
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