ID   C0P0L8_AJECG            Unreviewed;       431 AA.
AC   C0P0L8;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Serine/threonine phosphatase {ECO:0000313|EMBL:EEH02838.1};
GN   ORFNames=HCBG_08948 {ECO:0000313|EMBL:EEH02838.1};
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093 {ECO:0000313|EMBL:EEH02838.1, ECO:0000313|Proteomes:UP000001631};
RN   [1] {ECO:0000313|Proteomes:UP000001631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432
RC   {ECO:0000313|Proteomes:UP000001631};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG663381; EEH02838.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0P0L8; -.
DR   STRING; 447093.C0P0L8; -.
DR   VEuPathDB; FungiDB:I7I50_05308; -.
DR   HOGENOM; CLU_023125_0_0_1; -.
DR   InParanoid; C0P0L8; -.
DR   OrthoDB; 1353at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd00144; MPP_PPP_family; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR42850; METALLOPHOSPHOESTERASE; 1.
DR   PANTHER; PTHR42850:SF4; METALLOPHOSPHOESTERASE YNL217W-RELATED; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001631};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        156..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          238..401
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
FT   REGION          314..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   431 AA;  48175 MW;  8FE610C40F543300 CRC64;
     MVALRLRKGS MVLRMFSFRQ QRQQRRQRRH VQLSKSIHRP GLKPVDKSNS SYTGILDEGK
     PFALAETPLP EESPWREALS PGWSIGFQNM AGPMPSTSYP RPPPRPLIDY VTNGWMTAEQ
     KHSNLGPNSK AGGSNYCPAS MKGLLILASA PRLRRYIIVY LILLWICLGS WIKLVSPRLR
     EHNDLLRALD PNFGDGLRGW FGLNSMPKFN DLVYLRSLDP TLLPGEKEPT ADNPHKKRLI
     VIGDVHGCLD ELETLLQNVN FEPRQGDHLI FTGDLIAKGP KSTGVVDLAR KFHASCVRGN
     HEDRVLLTRR HIQAEASTKS ERSAAEEPDQ IDDDIEPANR ERALANELTD EQAKWLDACP
     VMLKVGFIKH MGEVVVVHGG LVPGIDLESQ DPSTVMSMRT IDIFSHVPSA SSKGVSWTKL
     IFALIPFLVA I
//