ID C0QJF4_DESAH Unreviewed; 438 AA.
AC C0QJF4;
DT 05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Zn-dependent metalloprotease (TPR repeat protein) {ECO:0000313|EMBL:ACN15967.1};
DE EC=3.4.-.- {ECO:0000313|EMBL:ACN15967.1};
GN OrderedLocusNames=HRM2_28790 {ECO:0000313|EMBL:ACN15967.1};
OS Desulforapulum autotrophicum (strain ATCC 43914 / DSM 3382 / VKM B-1955 /
OS HRM2) (Desulfobacterium autotrophicum).
OC Bacteria; Thermodesulfobacteriota; Desulfobacteria; Desulfobacterales;
OC Desulfobacteraceae; Desulforapulum.
OX NCBI_TaxID=177437 {ECO:0000313|EMBL:ACN15967.1, ECO:0000313|Proteomes:UP000000442};
RN [1] {ECO:0000313|EMBL:ACN15967.1, ECO:0000313|Proteomes:UP000000442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43914 / DSM 3382 / HRM2
RC {ECO:0000313|Proteomes:UP000000442};
RX PubMed=19187283; DOI=10.1111/j.1462-2920.2008.01825.x;
RA Strittmatter A.W., Liesegang H., Rabus R., Decker I., Amann J., Andres S.,
RA Henne A., Fricke W.F., Martinez-Arias R., Bartels D., Goesmann A.,
RA Krause L., Puehler A., Klenk H.P., Richter M., Schuler M., Gloeckner F.O.,
RA Meyerdierks A., Gottschalk G., Amann R.;
RT "Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate
RT reducer oxidizing organic carbon completely to carbon dioxide.";
RL Environ. Microbiol. 11:1038-1055(2009).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003983};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU003983};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}.
CC -!- SIMILARITY: Belongs to the peptidase M48 family.
CC {ECO:0000256|RuleBase:RU003983}.
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DR EMBL; CP001087; ACN15967.1; -; Genomic_DNA.
DR RefSeq; WP_015904729.1; NC_012108.1.
DR AlphaFoldDB; C0QJF4; -.
DR STRING; 177437.HRM2_28790; -.
DR KEGG; dat:HRM2_28790; -.
DR eggNOG; COG4783; Bacteria.
DR HOGENOM; CLU_039394_0_0_7; -.
DR OrthoDB; 9810445at2; -.
DR Proteomes; UP000000442; Chromosome.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2010.10; Metalloproteases ('zincins'), catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001915; Peptidase_M48.
DR InterPro; IPR006311; TAT_signal.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR22726; METALLOENDOPEPTIDASE OMA1; 1.
DR PANTHER; PTHR22726:SF1; METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL; 1.
DR Pfam; PF01435; Peptidase_M48; 1.
DR Pfam; PF13432; TPR_16; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51318; TAT; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003983};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Membrane {ECO:0000256|ARBA:ARBA00022792};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003983};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003983};
KW Reference proteome {ECO:0000313|Proteomes:UP000000442};
KW Signal {ECO:0000256|SAM:SignalP};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003983}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..438
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002902411"
FT DOMAIN 72..250
FT /note="Peptidase M48"
FT /evidence="ECO:0000259|Pfam:PF01435"
FT REPEAT 287..320
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 438 AA; 47850 MW; 7A4AC9BCE42EA880 CRC64;
MVADTPMTRR TFISGSLALG AGVALAGCAV NPVTGKNQFM MVTPEQEVAM DRIQSPHQFS
ADYGAVQDQG VNTYVTEIGT KLSALTHRPR MPYSFQCVNA TYINAYAFPG GSIAVTRGIL
LKLSNEAELA ALLGHELGHV NARHSAQQIS KSTLSSIFIS GVAAAVGTQG QGLGDVARQI
GMLGQGALLA RYSRDNEREA DALGNEYMVK AGYSSMGFVG LMGILNTLNK NKASSTDILF
STHPMSDERY GTAVARSRNP YGYSSGFSLN QERYMDNTAS VRADRAAIEA LQAGDQYMAK
KEYQTAETQF AKAIKLAPED YTAHVMQAKC MLETRRFERA ATHADLAVTL YPDEPQAQYV
AGFVHLNLNQ FARAFERFDR YAGLLPGNPG AIFFKGYCQE KMEHVASAAE FYKLYLNEVQ
QGEYAVHAHG RLKQWGYL
//
