ID C1E8W3_MICCC Unreviewed; 448 AA.
AC C1E8W3;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Ketopantoate reductase N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MICPUN_59513 {ECO:0000313|EMBL:ACO64578.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO64578.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO64578.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001327; ACO64578.1; -; Genomic_DNA.
DR RefSeq; XP_002503320.1; XM_002503274.1.
DR AlphaFoldDB; C1E8W3; -.
DR GeneID; 8244257; -.
DR KEGG; mis:MICPUN_59513; -.
DR eggNOG; ENOG502S6M1; Eukaryota.
DR InParanoid; C1E8W3; -.
DR OrthoDB; 5478361at2759; -.
DR Proteomes; UP000002009; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR21708:SF26; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..158
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 238..357
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 448 AA; 47772 MW; 2D8FBA0033550B2B CRC64;
MKTPELHHSS GRRVDMPLKV GVLGAGAVGA YVGGLIALRT KSDVVMVGRR RFVDQVSAGG
VTLRPDPRRP RDVHSIRAMH VTVDDDPKAL AGCDIVLVAV KSTATADAAA QLERIAERGG
FPPHALVLSL QNGVGNGSIL VRALEKHGVA TLPCMVNFNV VWDSYASDDV RDGCKIRRCT
PAKPGMPCVG IHNLPERAEA DGTGLVDHPS VFAAKKANLA AFVEALRETG LAVSLERDIL
PVQYGKLLIN LQSPVNAISG APVPTTLSRR RFRMAWRALV LEALDVFRAC GIKPARPYVP
FLPFVLALPD WAYNAAAFAL FPLDPGCKSS MLQDCETGRA TEIDALCGEI VRLARRNANR
ARDEDAGAGG EGGDDARGIG RGIGRALAAL GFGFGGFGFG FGFGRGSSRR GRTAPLNARA
IELVRRLERV GLPDGRMGPD ELWEALTR
//
