ID C1F1P1_ACIC5 Unreviewed; 668 AA.
AC C1F1P1;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=ATP-dependent DNA helicase RecQ {ECO:0000313|EMBL:ACO34595.1};
DE EC=3.6.1.- {ECO:0000313|EMBL:ACO34595.1};
GN Name=recQ {ECO:0000313|EMBL:ACO34595.1};
GN OrderedLocusNames=ACP_0647 {ECO:0000313|EMBL:ACO34595.1};
OS Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM
OS 7670 / NBRC 15755 / NCIMB 13165 / 161).
OC Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC Acidobacterium.
OX NCBI_TaxID=240015 {ECO:0000313|EMBL:ACO34595.1, ECO:0000313|Proteomes:UP000002207};
RN [1] {ECO:0000313|EMBL:ACO34595.1, ECO:0000313|Proteomes:UP000002207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 /
RC NCIMB 13165 / 161 {ECO:0000313|Proteomes:UP000002207};
RX PubMed=19201974; DOI=10.1128/AEM.02294-08;
RA Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT "Three genomes from the phylum Acidobacteria provide insight into the
RT lifestyles of these microorganisms in soils.";
RL Appl. Environ. Microbiol. 75:2046-2056(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; CP001472; ACO34595.1; -; Genomic_DNA.
DR RefSeq; WP_015895827.1; NC_012483.1.
DR AlphaFoldDB; C1F1P1; -.
DR STRING; 240015.ACP_0647; -.
DR KEGG; aca:ACP_0647; -.
DR eggNOG; COG0514; Bacteria.
DR HOGENOM; CLU_001103_14_3_0; -.
DR InParanoid; C1F1P1; -.
DR OrthoDB; 9763310at2; -.
DR Proteomes; UP000002207; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ACO34595.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ACO34595.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002207}.
FT DOMAIN 24..192
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 218..361
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 595..668
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 668 AA; 72961 MW; 0C73F821CB57FF05 CRC64;
MELVELLRSV FGFAGFRENQ EAVCRAVAGG RDALLVMPTG AGKSICYQLP ALARGGPAVV
VSPLIALMDD QAGRLASHGV RTARIHSGVP REEARQACRD YLDGTLQFLF IAPERLRVPG
FPEMLARRTP ALIAVDEAHC ISGWGHDFRP DYRTLGEWLP MLRPAPIIAL TATATPRVQQ
DIVTQLRLEN PALFVHGFRR ENLALEVVEM SKPRRHGFIQ DYLKAAERRP AIVYAPSRKA
ADELAAELGE RFPAAAYHAG LEPAVRERVQ KGFLAGEIEV VVATIAFGMG IDKADIRTVM
HAALPGSVEA YYQEIGRAGR DGRRSRAILL HSFADRKMHE SFFERDYPPV EDLARVARVL
TEEFAAPEEL WEKLRMSPEV FGRAVDKLAA QGAAAFDVEG RVRGLLRATD AGRWRGGYQA
QREHRQAQLD DMAAFAEGAQ CRMSALVRHF GDTPGAPCGI CDFCSPETAA AARFVEPDAQ
EGRQLRRILR ELKEGGGRSV GRLQTEAGVD GDRRAFDALL DGLARAGMVT LTTETWTNPE
GREVTYRKAA LTYEGRGWQE PEPLPVLLRA VGEDGAAAAP KKKKKAAPEV AVELTAEQTE
LENRLRAWRK AEASATGKPA FLVLTDAALR GLAAAGPRNL AELTGIHGIG PVKAERYGAE
LVAICRGD
//
