ID C1F2U8_ACIC5 Unreviewed; 352 AA.
AC C1F2U8;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Threonine aldolase, low-specificity {ECO:0000313|EMBL:ACO31336.1};
DE EC=4.1.2.5 {ECO:0000313|EMBL:ACO31336.1};
GN Name=ltaE {ECO:0000313|EMBL:ACO31336.1};
GN OrderedLocusNames=ACP_0847 {ECO:0000313|EMBL:ACO31336.1};
OS Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM
OS 7670 / NBRC 15755 / NCIMB 13165 / 161).
OC Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC Acidobacterium.
OX NCBI_TaxID=240015 {ECO:0000313|EMBL:ACO31336.1, ECO:0000313|Proteomes:UP000002207};
RN [1] {ECO:0000313|EMBL:ACO31336.1, ECO:0000313|Proteomes:UP000002207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 /
RC NCIMB 13165 / 161 {ECO:0000313|Proteomes:UP000002207};
RX PubMed=19201974; DOI=10.1128/AEM.02294-08;
RA Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT "Three genomes from the phylum Acidobacteria provide insight into the
RT lifestyles of these microorganisms in soils.";
RL Appl. Environ. Microbiol. 75:2046-2056(2009).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the threonine aldolase family.
CC {ECO:0000256|ARBA:ARBA00006966}.
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DR EMBL; CP001472; ACO31336.1; -; Genomic_DNA.
DR AlphaFoldDB; C1F2U8; -.
DR STRING; 240015.ACP_0847; -.
DR KEGG; aca:ACP_0847; -.
DR eggNOG; COG2008; Bacteria.
DR HOGENOM; CLU_029381_0_4_0; -.
DR InParanoid; C1F2U8; -.
DR Proteomes; UP000002207; Chromosome.
DR GO; GO:0004793; F:threonine aldolase activity; IEA:UniProtKB-EC.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR CDD; cd06502; TA_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR023603; Low_specificity_L-TA-like.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; NF041359; GntG_guanitoxin; 1.
DR PANTHER; PTHR48097:SF9; L-THREONINE ALDOLASE; 1.
DR PANTHER; PTHR48097; L-THREONINE ALDOLASE-RELATED; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR PIRSF; PIRSF017617; Thr_aldolase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:ACO31336.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002207}.
FT DOMAIN 13..295
FT /note="Aromatic amino acid beta-eliminating lyase/threonine
FT aldolase"
FT /evidence="ECO:0000259|Pfam:PF01212"
FT MOD_RES 209
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR017617-1"
SQ SEQUENCE 352 AA; 37456 MW; AC59F39FCFDA18BC CRC64;
MSAANGKPST IIDLRSDTVT VPTPEMWAAM AAAEVGDDVY GEDPTVNRLE ARAAATFGRE
AALFMPTGTM GNQTAIRLHT RPGQEVVCEA RAHIVDWEMA MVSAFSGCQL RTVAAQRGVL
TWQHIKTALS PKIYYRAQTG LISLENTHNM AGGTVTPLEV LEEIWAGAKD AGLPVHLDGA
RVFNAAAALG VEVARLTRGF DSVMFCLSKG LSAPVGSLLV GSREFIDRAR PVRKMLGGGM
RQAGVLAAAG LIALEEMPKR LPEDHANARL LAERIADCKE VELDLEAVET NIVIFTLRGQ
GDAAALVARL KQRGVAASAV GPHAVRFVSH RNVDRAACEQ AAQVAVEEMG KG
//
