ID C1FD55_MICCC Unreviewed; 794 AA.
AC C1FD55;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=MCM9 {ECO:0000313|EMBL:ACO68334.1};
GN ORFNames=MICPUN_113396 {ECO:0000313|EMBL:ACO68334.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO68334.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO68334.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
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DR EMBL; CP001574; ACO68334.1; -; Genomic_DNA.
DR RefSeq; XP_002507076.1; XM_002507030.1.
DR AlphaFoldDB; C1FD55; -.
DR STRING; 296587.C1FD55; -.
DR GeneID; 8250392; -.
DR KEGG; mis:MICPUN_113396; -.
DR eggNOG; KOG0478; Eukaryota.
DR InParanoid; C1FD55; -.
DR OrthoDB; 147095at2759; -.
DR Proteomes; UP000002009; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF48; DNA HELICASE MCM9; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 392..599
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 794 AA; 87944 MW; 6D9C18083B3F7803 CRC64;
MILIFGLFVD FFTCRWSTPT ISFLRAYLIL GLLEYLYTFV IPGICACWSS GRQGGVLVYY
SQLGLSSEGL SSEGLRLSFE DLLMGESYRS QMHGILLVIV FFVMVALMRS HAAILGLSAN
SIKYSARVRL DFHRIALLQL GSFVSQLCAP YSGHILTIQG TVTRVSAVRS CEVEQLFECD
FCKHRFSVPV SQGQKLYFAA PKTCPRSLTS ASTAAKPDAA ACAGTSFSVV QTKLPILNDF
QEIHVQDSSW AFSERTKTCL QLDLTLLGTD GWFKKRQNQR TSNIKAPQRS IAVILVDDLV
DKCRPGDDIC ITVTVLSRWL KARCGQRAEV EMICSAISVS YLPNGMFCEH QRACKEDVDD
FASFWRYGAH HTTASRLEEP AAAKMQQTIC AGRDLLLDSF CPQLFQLYPA KLAFLLSLVG
GVSYIEYETG NHNRNECHVL LIGDPGTGKS QLLKYVAKLA PKSVNATGTG LTSAGLTATM
RKGKDSNSWI LDAGVLVLAD SGVCCIDQFE KISGAQLAAF QEAMEQQTLS ITMETMVARL
QTRCSLFASA NPVAGRIDTA LSLSANTGLQ SPILSRFDCI LVFKDDMSSR HDRAISSHLT
SHNQRNYVDN INHELSAIDR VDNERKSSLM NRQGFSCQAL NRGKGYLSFK AKDTHAGMLS
QNRHKLWSFQ HVRRYVLLVR YAIDPVLSSE AEMLIRGFYQ VCRRERAGLS ARPTIRLLVS
LIRLSQAHAK LLWNQQVRGG DVVVAVDILK ASNDYTLPAH LGSTCSTLMP EASAMLQREI
QLIGDIERVL GPSW
//
