ID C1FD97_MICCC Unreviewed; 955 AA.
AC C1FD97;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=GPI ethanolamine phosphate transferase 3 {ECO:0000256|ARBA:ARBA00020841};
GN Name=PIGO {ECO:0000313|EMBL:ACO68353.1};
GN ORFNames=MICPUN_113927 {ECO:0000313|EMBL:ACO68353.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO68353.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO68353.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
CC {ECO:0000256|ARBA:ARBA00008695}.
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DR EMBL; CP001574; ACO68353.1; -; Genomic_DNA.
DR RefSeq; XP_002507095.1; XM_002507049.1.
DR AlphaFoldDB; C1FD97; -.
DR STRING; 296587.C1FD97; -.
DR GeneID; 8250413; -.
DR KEGG; mis:MICPUN_113927; -.
DR eggNOG; KOG2126; Eukaryota.
DR InParanoid; C1FD97; -.
DR OrthoDB; 5479199at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000002009; Chromosome 1.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16023; GPI_EPT_3; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037675; PIG-O_N.
DR InterPro; IPR045687; PIGG/GPI7_C.
DR InterPro; IPR039524; PIGO/GPI13.
DR PANTHER; PTHR23071:SF1; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3; 1.
DR PANTHER; PTHR23071; PHOSPHATIDYLINOSITOL GLYCAN; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF19316; PIGO_PIGG; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACO68353.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 487..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 681..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 714..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 892..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 795..935
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
SQ SEQUENCE 955 AA; 105242 MW; 7E65403269E7BD31 CRC64;
MLRTDLSSGT FGGVRFPLFV FLVLLAVGKT LALLIYGSGF YLTRMQLLNA NTCDFQRNAS
QEFRYNQALT PYDLSPGDAE CWTETRVDKV VLMIIDGARF DFAAASFNSK ENVWSGNSPL
SSIAETVQKY PETTELYRFV ADPPTTTQQR LKSILTGGLP TFLEISKSFG AAKLVEDNLI
SQAAAAGRRI SFSGDDTWLE LFHHVHFAAS VDAHPSFNVR DLDSVDQGVR RHLLTALDNP
DDWDILIGHF LGVDHAGHTY GVESQAMIKK LQENDADIKA ISSAMRADSA FDNALLIVMG
DHGMTLHGDH GGGTSAETDS FLLIHQPRAS SLQEVTQHKN SSKALSNLDL KTMSQIDFAP
TLSTILDIPI PYGSLGAIQR RFLEVASTLD PRKETHALHM NNQVIEEWYL RALRGATMQV
WRYLNAYVIE AGNPFSVDDW SRLQDLYNSS QSLTASDGDR VQMLEGFLSI AAETSRERWI
QFSIRKMAVG VVLLICLLAI CAMSKLLFLC EDAVVDARWK SILSRINAIH NMFESRAVHM
EMIFLLIVAG LISGYRVSNS FITAEADVAH FIVASFALFF SVFRISFLRR ALRSQIRSDA
ALQSGLGAAL LTCNTGCQLL GATWLKHADH GASRHVLPMT LSFLSRTIIF CAHGALPWIC
HRAMIQGNAN GQRACITLAS ASLGLLTFKH GTCFSVLLRL VGVGTLGPSV SPELFLPWVT
YIASSIAFIV PVGFGKRSLN RYKIQIDTHG TMWSLLSIFV LSFGERGSLW GVLSITQSAA
VLYSSSPGSA AVNYYNFREM TLALTWHVLA LQCFFAGGHH CTFDSLHLTC AFIGLNNFHF
VIMGILLSSN TWSGEALISG QIPTVVVSCL NSRRVDEEHL TKVLRNALSR FVLSYAVCRL
VTIVVISGFV GAERGHLMVW AVFAPKFAFD AAGQLFGDAW LIFGVLICVR HLHTE
//
