ID C1FGC9_MICCC Unreviewed; 759 AA.
AC C1FGC9;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN ORFNames=MICPUN_60822 {ECO:0000313|EMBL:ACO69236.1};
OS Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO69236.1, ECO:0000313|Proteomes:UP000002009};
RN [1] {ECO:0000313|EMBL:ACO69236.1, ECO:0000313|Proteomes:UP000002009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR EMBL; CP001575; ACO69236.1; -; Genomic_DNA.
DR RefSeq; XP_002507978.1; XM_002507932.1.
DR AlphaFoldDB; C1FGC9; -.
DR STRING; 296587.C1FGC9; -.
DR GeneID; 8245899; -.
DR KEGG; mis:MICPUN_60822; -.
DR eggNOG; KOG2657; Eukaryota.
DR InParanoid; C1FGC9; -.
DR OMA; DNIFAFP; -.
DR OrthoDB; 1330770at2759; -.
DR Proteomes; UP000002009; Chromosome 8.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..759
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002909450"
FT DOMAIN 47..215
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
FT REGION 256..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 79393 MW; 9E23190553639511 CRC64;
MLRLGTWLAL AILMASPRPG VDGYEPKRIR KVADLRDNMY PVMGHWPCVL LLNATGSAGC
STREPVWATL QRCEDMGCVR SIAGDRTLLL PPSVFPRAMR EYLDGSAPVD EGWRGRVRGM
LVEVGDGAGL NATDLGDASF SPQPAYPQAE LRPANDPGTH QWNPHGFGAT DRRFEDFPIA
LLDFEGTDLA RTFARVNHET EYVKPDRVAS ADFLMQSALS SKQKLGVPKV TEENSAYCLA
ARACLPIGGY SVIATSPPRA SPPVRSDDDG DARARPGRRT PFVLVSARLD ATAMFHDVAA
GANAAMSGLI VLLAAAEAYA AALRAAEAAV APGEAKATPA KRVAFAAFAA EDWGYAGSRR
FLWELAGGGA DAGFGAANVG DVLGLGDVDA AIELGAIGLA HRRIPPDVAS PAVFVHAAPG
VGGAGLADAI IKTGADVPGV SLRRSADGVP FPPSSTFSLL RRDAAIPAAV LAEYDDRYID
PFYGGAFDSG VDAVDPARMA RVAVVLAKTL LNVAAGFPPG SAQLARATEG VDGAGVDATT
RELVTCLVDP AVGFDCDRAR ALFSHATGRW SSRYAGVLPG LLAKDHQSPL GKSDVQRFAW
NFLANATADR HLSSFKSCAS QEECGGGGGG GDVAEVCVGA TGDRGGFFGR QERLRSKRRR
LIERDERRGD ASRLGADDGT SALYGQLDGD DGTSAEPGAC VAASVGFVPA LSHRLAFDAT
ELIWRLGATD PTELALGGGE DPVWTESNWP GSVGITATV
//
