ID   C1G018_PARBD            Unreviewed;       619 AA.
AC   C1G018;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 2.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Choline-sulfatase {ECO:0000313|EMBL:EEH43919.2};
GN   ORFNames=PADG_00208 {ECO:0000313|EMBL:EEH43919.2};
OS   Paracoccidioides brasiliensis (strain Pb18).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH43919.2, ECO:0000313|Proteomes:UP000001628};
RN   [1] {ECO:0000313|EMBL:EEH43919.2, ECO:0000313|Proteomes:UP000001628}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pb18 {ECO:0000313|EMBL:EEH43919.2,
RC   ECO:0000313|Proteomes:UP000001628};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
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DR   EMBL; KN275957; EEH43919.2; -; Genomic_DNA.
DR   RefSeq; XP_010755734.1; XM_010757432.1.
DR   AlphaFoldDB; C1G018; -.
DR   STRING; 502780.C1G018; -.
DR   GeneID; 22580085; -.
DR   KEGG; pbn:PADG_00208; -.
DR   VEuPathDB; FungiDB:PADG_00208; -.
DR   eggNOG; KOG3867; Eukaryota.
DR   HOGENOM; CLU_006332_9_1_1; -.
DR   InParanoid; C1G018; -.
DR   OMA; RAYFGAC; -.
DR   OrthoDB; 5488719at2759; -.
DR   Proteomes; UP000001628; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd16032; choline-sulfatase; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR017785; Choline-sulfatase.
DR   InterPro; IPR025863; Choline_sulf_C_dom.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   NCBIfam; TIGR03417; chol_sulfatase; 1.
DR   PANTHER; PTHR45953; IDURONATE 2-SULFATASE; 1.
DR   PANTHER; PTHR45953:SF1; IDURONATE 2-SULFATASE; 1.
DR   Pfam; PF12411; Choline_sulf_C; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001628}.
FT   DOMAIN          7..350
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   DOMAIN          550..604
FT                   /note="Choline sulfatase enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12411"
FT   REGION          456..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..478
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..496
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   619 AA;  69093 MW;  69FB09BF30179536 CRC64;
     MKSPEKPSIL YIMADQMAAP LLSLYDENSP IKTPNLERLA REGVCFESAY CNSPLCAPSR
     FSMVTGQLPS KTGGYDNASD LPADTPTYAH YLRKEGYHTA LAGKMHFVGP DQLHGYEQRL
     TSDIYPGDYG WTVNWDEPEV RPDWYHDMSS VLEAGPCVRT NQLDYDDEVI HRATQYLYDH
     TRHRAGQPFC LTVSMTHPHD PYAMTKEYWD LYEDIDIPLP KTPVIPHDEQ DPHSQRVLKS
     IDLFGKEIPE QCILAARRAY FAACSYVDSQ VGRLMATLKA CDLADNTIVV FTGDHGDMLG
     ERGLWYKMVW YEHAARVPMF VHAPGRYKPK RVKENVSTMD LLPTFAAMAG GEINNHLPID
     GVSLMPYLLD SDSREAVSGL KTDTVIGEYM AEGTLAPVVM IRRGPWKFIY SPIDPPMLFN
     VKRDPTEAVN LASGIDIPTR PLLSLNESLS LSAAKQQTKP FATSPAPLPT PNISPPPGTL
     QVPYSTEYKT NSAQIPTPPR SPSPGKESAD TGTDEHTATD TNTSQTDIQS LLSAFISEAH
     SRWDFTALRE QVLHSQRRRR LVYSALVKGQ MTSWDYSPVT DGSAQYIRNH NRGVLGDIEL
     LSRWPRVVQW GGGAGRNGV
//