ID C1G0I2_PARBD Unreviewed; 684 AA.
AC C1G0I2;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=polynucleotide adenylyltransferase {ECO:0000256|ARBA:ARBA00012388};
DE EC=2.7.7.19 {ECO:0000256|ARBA:ARBA00012388};
GN ORFNames=PADG_00372 {ECO:0000313|EMBL:EEH44083.1};
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH44083.1, ECO:0000313|Proteomes:UP000001628};
RN [1] {ECO:0000313|EMBL:EEH44083.1, ECO:0000313|Proteomes:UP000001628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18 {ECO:0000313|EMBL:EEH44083.1,
RC ECO:0000313|Proteomes:UP000001628};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B-like family.
CC {ECO:0000256|ARBA:ARBA00008593}.
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DR EMBL; KN275957; EEH44083.1; -; Genomic_DNA.
DR RefSeq; XP_010756320.1; XM_010758018.1.
DR AlphaFoldDB; C1G0I2; -.
DR STRING; 502780.C1G0I2; -.
DR GeneID; 22580220; -.
DR KEGG; pbn:PADG_00372; -.
DR VEuPathDB; FungiDB:PADG_00372; -.
DR eggNOG; KOG1906; Eukaryota.
DR HOGENOM; CLU_013572_2_1_1; -.
DR InParanoid; C1G0I2; -.
DR OMA; IPEHHLG; -.
DR OrthoDB; 21395at2759; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProt.
DR CDD; cd05402; NT_PAP_TUTase; 1.
DR Gene3D; 1.10.1410.10; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002058; PAP_assoc.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR InterPro; IPR045862; Trf4-like.
DR PANTHER; PTHR23092:SF15; INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED; 1.
DR PANTHER; PTHR23092; POLY(A) RNA POLYMERASE; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR Pfam; PF03828; PAP_assoc; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001628}.
FT DOMAIN 288..385
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 453..510
FT /note="PAP-associated"
FT /evidence="ECO:0000259|Pfam:PF03828"
FT REGION 1..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..606
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 76947 MW; B806C12B1216CC11 CRC64;
MSPAFEFRGN RQGGNHRQQP EFTFRSRFPK TSARPLLLML QRETTPEFLG GSQSEEQKPR
KFIALEDLSD SDEAEMEVSS ADEGSHPPPR KKQAIESNTG PVAQVPKWSN PDPYTVLPPY
DENPAKRRDV VKLIRKARIQ QSVDQPKPEE KNAVVSNDDF ISFGLDDIEM DVPPENAPRG
PKSSMNQDGD PALGSRKRTY DDEITGPNKR PGKPGKPDRF SNSDGSMLLK WRPFDDQNPT
PWVDSVCRST FHVGCSLHNE ILSFYHWVKP KSFEHLIRND LIVRLQRLFE RRHYGSQLHA
FGSFASGLYL PTADMDLVLL SRQFLRQNRK TLCQRTREIY SFTAYLKDLD IAVPGSIETI
AHAKVPIIKF VDRLTGLKVD LSFDNSTGLA ANKTFQVWKS QFPAMPVIVS VIKQFLLLRG
LNEVPTGGLG GFSIICLVTS LLQHLPYSGA EPNLGGVLMD FFDFYGNKFN FSAVGIQFDP
PGYFDKKLLG VYLANRQQRL SIMDPNNPDN DIAGGTKEIQ LIFRTFADAY RTLRQELVQT
AFSGTRRDSL LGLILGANYE TYEHQRAHLD VLCKNDPRFA HYVQPPPPNN PPPEEPAAPP
SPPPVDADIL TAKGNEQEDS SQGLKLSRKK SVAFDRAARL KQLRPDLKHV PKFLDLDAAL
KLGGYSSISE MDRDLYLREK ALLG
//
