ID C1G8H4_PARBD Unreviewed; 844 AA.
AC C1G8H4;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Translation elongation factor Tu {ECO:0000313|EMBL:EEH47476.2};
GN ORFNames=PADG_03560 {ECO:0000313|EMBL:EEH47476.2};
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH47476.2, ECO:0000313|Proteomes:UP000001628};
RN [1] {ECO:0000313|EMBL:EEH47476.2, ECO:0000313|Proteomes:UP000001628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18 {ECO:0000313|EMBL:EEH47476.2,
RC ECO:0000313|Proteomes:UP000001628};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249}.
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DR EMBL; KN275960; EEH47476.2; -; Genomic_DNA.
DR RefSeq; XP_010759091.1; XM_010760789.1.
DR AlphaFoldDB; C1G8H4; -.
DR STRING; 502780.C1G8H4; -.
DR GeneID; 22582850; -.
DR KEGG; pbn:PADG_03560; -.
DR VEuPathDB; FungiDB:PADG_03560; -.
DR eggNOG; KOG0458; Eukaryota.
DR HOGENOM; CLU_007265_3_2_1; -.
DR InParanoid; C1G8H4; -.
DR OMA; FRMAISE; -.
DR OrthoDB; 5477300at2759; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd16267; HBS1-like_II; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR015033; HBS1-like_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR PANTHER; PTHR23115:SF309; ELONGATION FACTOR EF-1 SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04630)-RELATED; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR Pfam; PF08938; HBS1_N; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000313|EMBL:EEH47476.2};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:EEH47476.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001628};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 433..660
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 91018 MW; BC68DD234401C401 CRC64;
MSRNRVKNIA YDDDDCASDD YDYDDYSTAP GTGPGHNDMT PEDREEMRQC TVLVRELLDA
DIPPVPASDE EIWEALWYYY FDIEKAVGWL RRKYTPKTPK AKAKAKGTHP SPSPYLIPEC
PQPFSTADFF KDSPWLNIPA QCKADILIEP LYPPLGLLGG APEASGKVSK LAALAARKRK
DNEHHKAASV AGSGSETASE ACSLSSDDQR SAPMSLLERL AVNGKSQGTA AVPARPIRLP
LRSGKGPLLN NKPKQPVSPL SSTATTEQPP INCTAEPMIG KRKAAAISIE TTEGRPSKLP
DLRAEPSAFA MVLIGMRGIG VGVGDDHRAS PPPKPITHNI DVMKFFGQDL TEAFDFAEPS
PDDIVINARE SAKGAKAKRT AAAAAAKGTG AASSRTLPAD VTDGVKQVSV QETVKVKSKN
LDVLAEYRKT ERKKAANFVV IGHVDAGKST LMGRLLYELK AVDQRTIDKY RRDADKIGKG
SFALAWVLDQ GSEERARGVT IDIATNQFTT ENTNFTVLDA PGHRDFVPNM IAGASQADFA
VLVLDATTGN FESGLRGQTK EHALLVRSMG VQKIVVAVNK MDAADWSQSR FDEMEQQISS
FLMTAGFQSK NISFIPCSGL RGDNVVARPD DKNAAWYTGK TLVEELDTSE PYTYALDKPL
RMTIADVFRG GVLNPLSISG RLDSGHLQVG DQLVTMPSGE RCTIKGVEVD REPSDWAVAG
QNVVLHLTNI DSAHVRSGDV LCSPTSPVKN ITSFTAKVLA FDHLTPMHID VHRGRLHVPG
RISRLVALLD KGSGGAVRKK PKIVGPGNVA RIVVEMERAI PLEAPGRVVL RAGGETVAAG
LLEG
//
