ID C1GDY1_PARBD Unreviewed; 741 AA.
AC C1GDY1;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 2.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=Golgi apyrase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PADG_05467 {ECO:0000313|EMBL:EEH49388.2};
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780 {ECO:0000313|EMBL:EEH49388.2, ECO:0000313|Proteomes:UP000001628};
RN [1] {ECO:0000313|EMBL:EEH49388.2, ECO:0000313|Proteomes:UP000001628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18 {ECO:0000313|EMBL:EEH49388.2,
RC ECO:0000313|Proteomes:UP000001628};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR EMBL; KN275962; EEH49388.2; -; Genomic_DNA.
DR RefSeq; XP_010760753.1; XM_010762451.1.
DR AlphaFoldDB; C1GDY1; -.
DR STRING; 502780.C1GDY1; -.
DR GeneID; 22584389; -.
DR KEGG; pbn:PADG_05467; -.
DR VEuPathDB; FungiDB:PADG_05467; -.
DR eggNOG; KOG1386; Eukaryota.
DR HOGENOM; CLU_010246_3_0_1; -.
DR InParanoid; C1GDY1; -.
DR OMA; TAYEVCF; -.
DR OrthoDB; 180318at2759; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017110; F:nucleoside diphosphate phosphatase activity; IEA:UniProt.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF121; NUCLEOSIDE-DIPHOSPHATASE MIG-23; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001628};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 538..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 711..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 145
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 182..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 741 AA; 81374 MW; 7AE011D66091BC31 CRC64;
MLTWRYAVVL DAGSSGTRSY VYRWPDSVKA RKSASAKELA SLPEIITSEE WTKKIHPGIS
TFAQNPQDVG LEHLRPLLHH VQEVIPEEDV PDTPFFLLAT AGMRLLPKAQ QKSILNNVCT
YVRQTTDFLI PDCNQHVQVI EGVTEGLYGW IATNYLMGGF DDSRSHNHGK GHHTYGFLDM
GGASAQIAFA PNATEAQKHA NDLTLLRLRS VNGRALEYKV FVMSWLGFGA QEARSRYVKA
LLESTVDEKN KGRPDPCLHA GLRMSADGTI LPPEGPVSGV EPYLVGTGKF DQCLLQTFPL
LEKDAPCPDE PCLLHGVHVP AIDFDVNHFI GVSEYWHTTH GIFDMGYKDD PYNFNDYLQR
AKDFCSQPWD EIEAGIRGQR WGGKVSKKTA NELCFKASWL INILHDGIGI PRSSIGEAEV
TIGHNNKTQD VVVSGKPDGY LDAFQAVNKI GATEVSWTLG KAVLYASSQV PPLKNGLPVG
FGSNVPGGVA DDFQHTGPQL QPLPPASQPT IPTNDTITGT NRQHWHDTLF DGHSPRRIPG
LFLFLAIVAI AIFFLYGRER RNRVYRRFLG RPISRHGSSI HYRRRSKGLY NSKLSSFFFF
SPSPRRSSYM PYERTLEDGM REFELGLGSS SSDDEASATY DEDGSSSVNL LARLKSSTST
SNNISSVGGG GGGGGNRASV GLGLSLDGNG SLLSLYNVGI MDRNGLAVRT ESRDRQAHLA
LAPTTNGRRS RATSPVRKSV V
//
