ID   C1GPT8_PARBA            Unreviewed;       767 AA.
AC   C1GPT8;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 2.
DT   03-MAY-2023, entry version 68.
DE   SubName: Full=Cullin-1 {ECO:0000313|EMBL:EEH36210.2};
GN   ORFNames=PAAG_00533 {ECO:0000313|EMBL:EEH36210.2};
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH36210.2, ECO:0000313|Proteomes:UP000002059};
RN   [1] {ECO:0000313|EMBL:EEH36210.2, ECO:0000313|Proteomes:UP000002059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; KN293992; EEH36210.2; -; Genomic_DNA.
DR   RefSeq; XP_015700386.1; XM_015844051.1.
DR   AlphaFoldDB; C1GPT8; -.
DR   STRING; 502779.C1GPT8; -.
DR   GeneID; 9101125; -.
DR   KEGG; pbl:PAAG_00533; -.
DR   VEuPathDB; FungiDB:PAAG_00533; -.
DR   eggNOG; KOG2166; Eukaryota.
DR   HOGENOM; CLU_004747_6_1_1; -.
DR   OMA; IREWDRY; -.
DR   OrthoDB; 5474206at2759; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF169; CULLIN-1; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002059}.
FT   DOMAIN          406..642
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   767 AA;  88646 MW;  16E0DFFDF18C1674 CRC64;
     MPPSGIQTPH KDDLEETWAY LEKGVERVMT QLEGGIDMLT YMGVYTAVHN FCTSQKAISS
     PSTPSSQGAH RGAHLLGEEL YNLLGIYLSR HLNDVYEASL GHSDEALLTF YIREWSRYTT
     AAKYINHLFK YLNRHWVKRE VDEGKKDIYD VYILHLVKWR EDFFKKVQKS VMDAVLKLIE
     KQRNGETIEQ SQIKNIVNSF VSLGLDENDS TKSTLVVYQF YFEKPFIEAT RVYYENESKR
     FVAENSVVEY MKKAEARLEE ERARVDLYLH PDITKNLTDT CLDVLVAAHS PLLRDEFQVL
     LDTEREDDLA RMYRLLSRIR DGLDPLRNKF ETHVRKAGLA AVEKVAPNGD AVEPKLYIDA
     LLQVHTKYQS MVNVAFAGES EFVRSLDNAC REFVNRNALC NTSSTKSPEL LARYTDSLLK
     KGVKSPEESE LEEMLVQIMT VFKYIEDKDV FQKFYSRMLA KRLVHVSSVS DDAETSMISK
     LKEACGFEYT NKLQRMFQDI QISKDLNASY RDWQEKVMDE EDRKKSVDPH FQILGTGFWP
     LTAPTTQFIP PQEIVKTTER FKNFYFDKHS GRKLTWLWNL CKGEIRANYI KNTKVPYTFQ
     VSTFQMGILL LFNESDTLSF SDIEKATALA PEVLEPNLGI LVKAKVVIPS PENGKPCVGT
     SYTLNYNFKA KKIKVNLNIS VKSEQKHETD DTHKTIDEDR KLLLQSAIVR IMKSRKKMKH
     VQLVQEVIQQ VKARFPPKVP DIKRNIEALM EKEYIERLDG DDLAYIA
//