ID C1GR52_PARBA Unreviewed; 1613 AA.
AC C1GR52;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Actin-interacting protein {ECO:0000313|EMBL:EEH38076.2};
GN ORFNames=PAAG_00997 {ECO:0000313|EMBL:EEH38076.2};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH38076.2, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:EEH38076.2, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KN293993; EEH38076.2; -; Genomic_DNA.
DR RefSeq; XP_015700988.1; XM_015844207.1.
DR AlphaFoldDB; C1GR52; -.
DR STRING; 502779.C1GR52; -.
DR GeneID; 9100657; -.
DR KEGG; pbl:PAAG_00997; -.
DR VEuPathDB; FungiDB:PAAG_00997; -.
DR eggNOG; KOG4711; Eukaryota.
DR HOGENOM; CLU_001127_2_1_1; -.
DR OMA; INEHFRH; -.
DR OrthoDB; 2692344at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR049453; Memb_transporter_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR47804; 60S RIBOSOMAL PROTEIN L19; 1.
DR PANTHER; PTHR47804:SF1; ARAE_2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13515; FUSC_2; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 9.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT TRANSMEM 685..703
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..756
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 762..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 792..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 822..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1283..1301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1307..1326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1333..1351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1371..1394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 54..86
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 185..226
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 229..270
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 533..566
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1254..1389
FT /note="Integral membrane bound transporter"
FT /evidence="ECO:0000259|Pfam:PF13515"
SQ SEQUENCE 1613 AA; 177724 MW; 188EC2BB318D73C6 CRC64;
MSIENEFILA PSPSTARAQP TQLACDSKGE RLAYASNKSI FLRSIDNPSI SRQYTGHKTP
TTVARFSPSG YYVASGDEAG TVRVWDCVGE GTTKGEYFIV SGRINDLAWD GDSQRIIAVG
DGREKYGRCI TADSGNSCGE VTGHTRRVNA VAIRQQRPIR AATAGDDMHV NFYHGVPFRV
NTRASENHVN YVCGLGFSPD GANLVSVGSD RRIWLYDGKT GETKTQIGAG EHTGSILGVS
WSPDSRKFVT ASADQTVKVW DVEQGKVVQN WKMGGDVAVS VSDQQVGVVW PNGRSDGLII
SLSLTGDLNY LVEGNEKLTR IVQSQQKEIT AFARYDVGDK QTLWTGGIDG KVYNWDLTQG
SAERVDGQGH PNYITGLAAT KEGNGHIYSV GWDDTIRAVD ASSNTYNGSA TKLASQPKNV
VTAGDNIVLV AKENGIVIFK DGSKVGDFGP SKSTINGIAA NGSSAAIGYA DSSVQICSIA
NNILSPSVEI KVSRDAVTSL AFSPNSSMLA VGDSRGRIVV YRTADGTIVT DRWTSHTARI
NSLAWNSEGS HLASGSLDTR IFVWSLACPG EWLTVAHAHQ EGVNGVVWIT DRTKIASVGA
DAALNHASFI LPRTGQRLRG LLNLSSYREN DDQEEREPLL ERRAAPQSQT ESVWHKCYQK
YRSLTHTLHP FITSELGKGV LKCSIAYMIG TLGTFLPAFA DFLGQQDGKH MVATVTVYFH
PARTKGSMIL ATIYAFLAFI YAALISVTSM GISVFFEDKL DLLPLGHAIV LLVFCGGGLG
FVGWVKLRRA DPLVNVACSL TSLAIINVLT KEGAVQQGDL SLVKIVQVLK MVVMGVIATT
AVCFLIFPVS ARTKLRKDLV EMTASLGTML AIITESFLQG SAEHLKQDSF QSALNRNKKA
YVTVEKWLKE EKVEHYLAGT EREYRLEKKL VRAIQDITQN IGGLQSAANL QFDLLRQSHQ
TNRNATPMSA GPSSYFTTQL CHSIFSPLPR SAHEETRRVL PGLERLQSDE PTPGHEQDSI
GTQAPADIFE RFIAHLGPSM RSLSYTVTEI LRELPYGPGP EYKVAVNCKF RISLDRALDL
YRNARNDALN LVYLQKDSVK TKSVEMEADL EEVAASCGHF SFSLQAFTEQ LKEILEILDE
LHLETEERPN GRSWGWLKFW RPTPPDHTNK WTSATRSATE RGETSIAPER YSIPETATSP
VDLAELSRKG KVRYKIWRAL RVFRRDDVKF AIKVGAGAAI YALPSFMPST RPFYSYWRGE
WGLLSYMLVC SMTIGASNTT GFARFFGTTF GAICAVVAWK VTSGEVFALA FICWVMAFCT
AHIILIKDRG PMGRFIMLTY NLTVLYAYSL SRDGIDDGED EGGRTPPVVD IAIHRVVSVL
SGILWGIIIT RVIWPISART KLKGGLSLLW LWMSVIWKRE PLTTMVDGNS AIAYFTPREK
LEFQRFMVSL ETLYNSARSE FELRGPFPEA IYISLLTRTR RMLDAIQAMN LEIMKNLTAS
EGEAAMLSYT LPERMQLSAR ISHLLSVVAS SMKLEYPLND ALPEIDHARD RLLARLHRFR
QDTSASRLTT DEDYALLYAY ALVTGQLGNE ITAIIGDLSK LFGILDEDVL KLE
//
