ID C1GVH8_PARBA Unreviewed; 318 AA.
AC C1GVH8;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 03-MAY-2023, entry version 58.
DE SubName: Full=mRNA decapping hydrolase {ECO:0000313|EMBL:EEH40200.1};
GN ORFNames=PAAG_02255 {ECO:0000313|EMBL:EEH40200.1};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH40200.1, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:EEH40200.1, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SIMILARITY: Belongs to the HIT family. {ECO:0000256|ARBA:ARBA00010208}.
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DR EMBL; KN293996; EEH40200.1; -; Genomic_DNA.
DR RefSeq; XP_002795549.1; XM_002795503.1.
DR AlphaFoldDB; C1GVH8; -.
DR STRING; 502779.C1GVH8; -.
DR GeneID; 9098840; -.
DR KEGG; pbl:PAAG_02255; -.
DR VEuPathDB; FungiDB:PAAG_02255; -.
DR eggNOG; KOG3969; Eukaryota.
DR HOGENOM; CLU_041045_0_0_1; -.
DR OMA; HVHINPI; -.
DR OrthoDB; 5490768at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR Gene3D; 3.30.200.40; Scavenger mRNA decapping enzyme, N-terminal domain; 1.
DR InterPro; IPR008594; DcpS/DCS2.
DR InterPro; IPR036265; HIT-like_sf.
DR InterPro; IPR011145; Scavenger_mRNA_decap_enz_N.
DR PANTHER; PTHR12978; HISTIDINE TRIAD HIT PROTEIN MEMBER; 1.
DR PANTHER; PTHR12978:SF0; M7GPPPX DIPHOSPHATASE; 1.
DR Pfam; PF05652; DcpS; 1.
DR Pfam; PF11969; DcpS_C; 1.
DR PIRSF; PIRSF028973; Scavenger_mRNA_decap_enz; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR SUPFAM; SSF102860; mRNA decapping enzyme DcpS N-terminal domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EEH40200.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059}.
FT ACT_SITE 245
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR028973-1"
SQ SEQUENCE 318 AA; 36453 MW; 1899F95BB45A42A5 CRC64;
MADGQEAESL IPKFKVERLL NQDQNDRRIS ILGSIDNTPG ILIAERAAFL SDPDSIRAFL
GALTNVTNLG ANDIYRWYLA STGQNHVSPP DLKLNLIWPC TEQHILKYSA QNLRMVTETP
EIYASYVRPY MQSKRENGRL NWVHNIVEGR KEQEDVILRV SDSEEGFLLL PDLNWDRKTL
GTLRLLCLVE RRDIWSLRDL KKKHIPWLSR MREQVLDGVV KVYPDLERDQ LKLYLHYQPT
YYHLHIHVVN IMLEAGTTQS TGKAFGLENL ISQLETMDGC LEAGMADVSL SYFIGEQSEL
WTNVFGPLKR GEEPKTAG
//
