ID C1GXA5_PARBA Unreviewed; 612 AA.
AC C1GXA5;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Multidrug transporter {ECO:0000313|EMBL:EEH41193.2};
GN ORFNames=PAAG_03479 {ECO:0000313|EMBL:EEH41193.2};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH41193.2, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:EEH41193.2, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KN293998; EEH41193.2; -; Genomic_DNA.
DR RefSeq; XP_015701956.1; XM_015844982.1.
DR AlphaFoldDB; C1GXA5; -.
DR GeneID; 9098035; -.
DR KEGG; pbl:PAAG_03479; -.
DR VEuPathDB; FungiDB:PAAG_03479; -.
DR eggNOG; KOG0255; Eukaryota.
DR HOGENOM; CLU_008455_0_3_1; -.
DR OMA; GPPHVHW; -.
DR OrthoDB; 1461033at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR23502; MAJOR FACILITATOR SUPERFAMILY; 1.
DR PANTHER; PTHR23502:SF3; MULTIDRUG EFFLUX PUMP OF PLASMA MEMBRANE (EUROFUNG); 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 247..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..555
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..92
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 68618 MW; B14B0982B17FEF94 CRC64;
MPASNPGTQP VQDRVRLHMR HKTYPRFIPR FNPSLRARLP SSAEHDVLHV SSFSSVPPGV
KGKDDTPHHD NEKPKLSPPP PLPPPPSPTS PPATKSQSSE RILLLESDCY GKLGFGFPRW
KKWTILSVVF FVQLSMNFNT SIYANAITPL SLHFSISEQA VRVGQMIFLV AYAFGSELWA
PWSEELGRYP VMQLSLSLVN IWQIPCALAK NFHTIVVGRF LGGLSSAGGS VTLGMIADMW
EPDDQQFAVA FIVLSSVAGS VIAPIVGGFM ETYLGWRWNF WVQLIFGGVA QAAHFLFVPE
TRVTILLDRE AKRRRQAGEL HIYGPGEIQG AGITLKEVAI IWARPFSMFV REPIVFCLSI
LSGFSDALIF TFLESYQPVY GQWGFNTIQI GLAFIPILLG YFIAYLSFLP VMIKHRKIQR
KDSSILEPES RLWWLLFTAP LETIGLFGFA WSSLGPPRIH WIAPMVFSLL IAVANYCIYM
ATIDYMVASY GPYSASATGG NALARDFLAG IAAMYSTPLY KTIGTKYQLE WPSTIMGIIS
FMVTIPIYIF YWKGSVIREK SKFAKILAND RKVRNIRRKG EKMRSDVEQT SESEIVQTME
RIYGVDSKNG IL
//
