ID   C1H1Y9_PARBA            Unreviewed;       448 AA.
AC   C1H1Y9;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 2.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Homoserine O-acetyltransferase {ECO:0000313|EMBL:EEH33876.2};
GN   ORFNames=PAAG_04925 {ECO:0000313|EMBL:EEH33876.2};
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH33876.2, ECO:0000313|Proteomes:UP000002059};
RN   [1] {ECO:0000313|EMBL:EEH33876.2, ECO:0000313|Proteomes:UP000002059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. MetX family.
CC       {ECO:0000256|ARBA:ARBA00006886}.
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DR   EMBL; KN294003; EEH33876.2; -; Genomic_DNA.
DR   RefSeq; XP_015699639.1; XM_015845413.1.
DR   AlphaFoldDB; C1H1Y9; -.
DR   STRING; 502779.C1H1Y9; -.
DR   GeneID; 9096506; -.
DR   KEGG; pbl:PAAG_04925; -.
DR   VEuPathDB; FungiDB:PAAG_04925; -.
DR   eggNOG; ENOG502QRIX; Eukaryota.
DR   HOGENOM; CLU_028760_5_0_1; -.
DR   OMA; SYLHYQG; -.
DR   OrthoDB; 2600616at2759; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   HAMAP; MF_00296; MetX_acyltransf; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR008220; HAT_MetX-like.
DR   NCBIfam; TIGR01392; homoserO_Ac_trn; 1.
DR   PANTHER; PTHR32268; HOMOSERINE O-ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR32268:SF11; HOMOSERINE O-ACETYLTRANSFERASE; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PIRSF; PIRSF000443; Homoser_Ac_trans; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EEH33876.2}.
FT   DOMAIN          49..392
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000259|Pfam:PF00561"
FT   REGION          204..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..225
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..287
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        120
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000443-1"
FT   ACT_SITE        359
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000443-1"
FT   ACT_SITE        388
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000443-1"
SQ   SEQUENCE   448 AA;  49609 MW;  B6028D7BFAC42882 CRC64;
     MPLPSPLNPE SHYAMSLSHI QQEENYQPLE TIADVSDWWG PLLGGPGQAF DVTRFFVVCL
     NSLGSPYGSA SAVTSRDGDK NKGIYGPEFP LTTIRDDVRI HKLVLDDLGV RQIASVVGGS
     MGGMLVLEYA FFGKDYVRSI VPIATSSRHS AWGISWGEAQ RQSIYSDPKY EDGYYSFDDP
     PATGLGAARM SALLTYRSRN SFESRFGRNV PDPSKRQNIN GTLRLPTPPN EHWAVHNDGH
     RSTRSPPAPN NSGPESNEVF TDPQFNGATL FTAPSSPTST APSERSWRPT TYFSAQSYLR
     YQGQKFVKRF DSNCYIAITR KLDTHDVSRH RADPDSTTPV KDALSQIQQP ALVIGIESDG
     LFTFAEQQEL ADGIPNSRLK NIDSPEGHDA FLLQFEQVNR YILEFFREVL PDIMNASGND
     TDGVVDHVGQ LTKSSTFGEA EVEDITAW
//