ID C1HCG0_PARBA Unreviewed; 490 AA.
AC C1HCG0;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=Acid phosphatase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PAAG_08451 {ECO:0000313|EMBL:EEH38724.1};
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH38724.1, ECO:0000313|Proteomes:UP000002059};
RN [1] {ECO:0000313|EMBL:EEH38724.1, ECO:0000313|Proteomes:UP000002059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR EMBL; KN294026; EEH38724.1; -; Genomic_DNA.
DR RefSeq; XP_002789605.1; XM_002789559.2.
DR AlphaFoldDB; C1HCG0; -.
DR STRING; 502779.C1HCG0; -.
DR GeneID; 9092856; -.
DR KEGG; pbl:PAAG_08451; -.
DR VEuPathDB; FungiDB:PAAG_08451; -.
DR eggNOG; ENOG502RCH9; Eukaryota.
DR HOGENOM; CLU_023111_1_0_1; -.
DR OMA; YIFHRHG; -.
DR OrthoDB; 2315929at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567:SF142; -; 1.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002059};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..490
FT /note="Acid phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002908931"
FT TRANSMEM 447..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 413..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 52842 MW; 4279F237228ED47F CRC64;
MRSRTMQPSS ALLALTVPLT IFTPAASSET VLGAYIFSRH GDRTAKSTPP TELTTLGYEQ
VFTTGAYYHD RYISPTSDLR ILNISSDIVK PKEVVASAPE DEVLQKSAIA FLQALYPPVG
GIAKSTLRNG TVVEAPLNGY QLVAIEQVST GGNSENLAWL QSASKCQKAK VSSNEYFTSK
PYEELLSSTN DFYKSIAPMV ERTLPASKVS YKDAYIIWDL LNVAMIHNST DSLPADKLPS
QENFDRLREL ADVHEFNLAY NASSPIRAVS GSTLAGEVLS GLREVISTGG SKTKLNVQFG
AYAIFLSFFG LSKLSETNPN FMKIPDYASS MAFELVTNAS TSSSSPFPNQ SDISVRFLFR
SGSVIPGAPE TMPVAYSLFG QSDTLMPWSE FESNMEKIAI STEKEFCEAC SETPERCDGG
SDGTDGTARA STGAGKRNGM STAVAGVVGA MVALAAIMGL QSFIFLAGGF RLVKKSDIKA
FREAERKIQP
//
