ID   C1HE41_PARBA            Unreviewed;       851 AA.
AC   C1HE41;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 2.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=AMP-dependent synthetase/ligase domain-containing protein {ECO:0000259|Pfam:PF00501};
GN   ORFNames=PAAG_09039 {ECO:0000313|EMBL:EEH40581.2};
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH40581.2, ECO:0000313|Proteomes:UP000002059};
RN   [1] {ECO:0000313|EMBL:EEH40581.2, ECO:0000313|Proteomes:UP000002059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- SIMILARITY: Belongs to the NRP synthetase family.
CC       {ECO:0000256|ARBA:ARBA00029454}.
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DR   EMBL; KN294054; EEH40581.2; -; Genomic_DNA.
DR   RefSeq; XP_015701756.1; XM_015846717.1.
DR   AlphaFoldDB; C1HE41; -.
DR   STRING; 502779.C1HE41; -.
DR   GeneID; 9092267; -.
DR   KEGG; pbl:PAAG_09039; -.
DR   VEuPathDB; FungiDB:PAAG_09039; -.
DR   eggNOG; KOG1178; Eukaryota.
DR   HOGENOM; CLU_000022_2_12_1; -.
DR   OMA; GCCCVPG; -.
DR   OrthoDB; 3305653at2759; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   CDD; cd05918; A_NRPS_SidN3_like; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   PANTHER; PTHR45527:SF3; SIDEROPHORE SYNTHETASE (EUROFUNG)-RELATED; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002059}.
FT   DOMAIN          277..611
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   REGION          802..851
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        806..828
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        829..843
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   851 AA;  93242 MW;  AC32FD3EEB576C36 CRC64;
     MAPSVLENST FTPYASNASS STSSMALETT KHSPSKIGCL ELALSEKSDV LEDVLKTETH
     GVSCNGNSTG LDNAFKILQL AWALTTRCFT STNSLLFESD TDLGISSLRE FSTKQGAQHG
     NRLLTIEPDD TLRQVLDKLE TVGRGVRQCA VSNQDGHIGT EVLNDLYTTA FRYRNASTSI
     LDIDLKVDVF LDITKTKDDQ LYSQLFFSSQ TISEPLASSV LHTFNQVLTS IRMSSDLTVE
     EINMCSPHDL EHISQLTSHV SDSYERCLHD MALEYSRTNP GAMAVVSWDG DLTYGELDDL
     TSRLSHCLVE LGVGPEVFVL SCFKKSTWAI VSRLAILRAG GAYISIDAAD PPAYLNSVIQ
     RAKPKVMLTV AEFSKQFQGL VPSIIELSKE GILNLPKKVE PACTTVQPNN ACLILFTSGS
     TGEPKGIIQE HRTYATAVRD YARILGLDTT TRMYQFDDYA FDISNNDYLV PLSVGGCCCV
     PHPQKAIHVL TKHMNDLGVN VSFLTPTVAI QLGPEDVPGL KTLCVGGEPP SSDLLAKWAG
     KVKLVNQYGM GEVATFCTYN DNMGPGSGTN IGRTGTGAAW VVSPSSPDRL MPVGSVGEMI
     MEGPHLARGY LDQIPRKSEA GFLQYTPKWL HELHPERTSS ARLYRSGDLV KYNHDGTLTY
     IGRKDTLLKI DGGRVDAIEV EYTARKCLSP GDSIVVDLLG AIDGVESPIL TAFLYLAVNP
     MNLCGKAGTN EPITFRMINE NHNAYSRVEL IKQVIGTSLP DIQIPTLFLL VDRIPHTKSN
     KTDRRKLHML GQNYYMPMRE ALDGGTSTKP VTQAHKEAPV NTCNSANRAK KRQVRELGDE
     ELKSKTQNQM C
//