ID C1N6S7_MICPC Unreviewed; 876 AA.
AC C1N6S7;
DT 26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT 26-MAY-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Mre11 DNA repair/recombination protein {ECO:0000313|EMBL:EEH51978.1};
GN Name=MRE11 {ECO:0000313|EMBL:EEH51978.1};
GN ORFNames=MICPUCDRAFT_70239 {ECO:0000313|EMBL:EEH51978.1};
OS Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Mamiellaceae; Micromonas.
OX NCBI_TaxID=564608 {ECO:0000313|Proteomes:UP000001876};
RN [1] {ECO:0000313|EMBL:EEH51978.1, ECO:0000313|Proteomes:UP000001876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1545 {ECO:0000313|EMBL:EEH51978.1,
RC ECO:0000313|Proteomes:UP000001876};
RX PubMed=19359590; DOI=10.1126/science.1167222;
RA Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W., Gready J.E.,
RA John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F., Moreau H.,
RA Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I., Piegu B.,
RA Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T., Zelensky A.,
RA Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W., Van de Peer Y.,
RA Grigoriev I.V.;
RT "Green evolution and dynamic adaptations revealed by genomes of the marine
RT picoeukaryotes Micromonas.";
RL Science 324:268-272(2009).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG663749; EEH51978.1; -; Genomic_DNA.
DR RefSeq; XP_003063605.1; XM_003063559.1.
DR AlphaFoldDB; C1N6S7; -.
DR STRING; 564608.C1N6S7; -.
DR GeneID; 9689225; -.
DR KEGG; mpp:MICPUCDRAFT_70239; -.
DR eggNOG; KOG2310; Eukaryota.
DR OMA; KGWGRSR; -.
DR OrthoDB; 169704at2759; -.
DR Proteomes; UP000001876; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.30.110.110; Mre11, capping domain; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR038487; Mre11_capping_dom.
DR InterPro; IPR007281; Mre11_DNA-bd.
DR InterPro; IPR041796; Mre11_N.
DR PANTHER; PTHR10139; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR PANTHER; PTHR10139:SF1; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF04152; Mre11_DNA_bind; 1.
DR SMART; SM01347; Mre11_DNA_bind; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001876}.
FT DOMAIN 306..505
FT /note="Mre11 DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01347"
FT REGION 442..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..729
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..788
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..823
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 876 AA; 93868 MW; 3904A2850188697F CRC64;
MADSDDLDLL RVLIATDNHL GVHEKDQVRK DDAFITFREI FEIAKQQKVD CVFLGGDLFD
INKPSRETMV RTMEILREYC LNDNPVQIEV LSDQTVNFPR RGVVNYEDPN YNVGLPVFMI
HGNHDDPAGG ENLSAIDVLA ACNLVNYFGK HTLGGSGTGK IKIKPVLLQK GETRIALYGL
GYIRDARLHQ MFSVKGNVEW ARPEDKEGMR VGSWFNAMLI HQNRVHHSPK NAISERYLPS
WLDLVVWGHE HECLVEPTED CTGNFSISQP GSSVVTSLIE GEAKKKQILL LEVRKDPDNP
DGAPFWRTTP IPLETPRPFK YVQLSLSDRA KLSAEDGGLG PDWNPGDVAG ARRGVKGRAG
GGAQHEAWVH GVLEKQVNDM IEDACAPFKQ RKVPSADIPL PLVRVRVDYT GGFSTINAQR
FGQKFVGKVA NPNDLLQFFK SAARRKKDEN EPSRPGAADE DEDEELINNP AVQDQKRIEK
LVSDNLSAGL QLLSENDLSN ALDDFVNRDA SAIVNLVKQR LKDTQTLAEE DGIGEDDDGF
MEDDAARRVE AAVQQRLARS APTAAAAAAA AAAAAGAGAA EPPAGPTPME AAAAEREKTR
RMMQTGAAAM NEEALDEDFG EDASAPAART ARDDDARHAA PAAKSPPAAA APARGRRSAA
AASSGGGGGG TLDAFLQPAS STGGRGGRGG RGGRAAGRGR GRGRGKAAAA DSDSGDDDVI
EDSEDSGDED VVPMSAPKRG GARPTRAAKA AAATRSRRGA AADTPDEFEF DEHSDDDDDD
DVVEDSGDDA EIATTNRRGA KRKAPAAAKK KSPAKKPKKS PAKKSPAKPP PGRARASRVI
EIDDSGDEDD EEVPATARGR ASRSRGGTQA SRGSRR
//
