ID C1QT3_HUMAN Reviewed; 246 AA.
AC Q9BXJ4; Q0VAN4; Q542Y2; Q6MZN1; Q96KY1;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 174.
DE RecName: Full=Complement C1q tumor necrosis factor-related protein 3;
DE AltName: Full=Collagenous repeat-containing sequence 26 kDa protein;
DE Short=CORS26;
DE AltName: Full=Secretory protein CORS26;
DE Flags: Precursor;
GN Name=C1QTNF3; Synonyms=CTRP3; ORFNames=UNQ753/PRO1484;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Piddington C.S., Bishop P.;
RT "Homo sapiens complement-c1q tumor necrosis factor-related protein.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Maeda T., Hayashi A., Saito T.;
RT "Molecular cloning, chromosomal localization, and genomic structure of the
RT human CORS26 gene.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
RX PubMed=20952387; DOI=10.1074/jbc.m110.180695;
RA Peterson J.M., Wei Z., Wong G.W.;
RT "C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates
RT hepatic glucose output.";
RL J. Biol. Chem. 285:39691-39701(2010).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Cerebellum, and Substantia nigra;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryo;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Salivary gland;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [11]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 121-246 (ISOFORM 1).
RC TISSUE=Aorta;
RA Hui R.T., Liu Y.Q., Wang X.Y., Qin B.M., Sheng H.;
RT "Homo sapiens normal aorta mRNA MST113.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [12]
RP TISSUE SPECIFICITY.
RX PubMed=14654242; DOI=10.1016/j.bbaexp.2003.08.013;
RA Schaffler A., Ehling A., Neumann E., Herfarth H., Paul G., Tarner I.,
RA Gay S., Scholmerich J., Muller-Ladner U.;
RT "Genomic organization, promoter, amino acid sequence, chromosomal
RT localization, and expression of the human gene for CORS-26 (collagenous
RT repeat-containing sequence of 26-kDa protein).";
RL Biochim. Biophys. Acta 1630:123-129(2003).
RN [13]
RP GLYCOSYLATION AT ASN-70 (ISOFORM 3).
RX PubMed=19139490; DOI=10.1074/mcp.m800504-mcp200;
RA Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B.,
RA Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L.,
RA Ying W.T., He S.M., Qian X.H.;
RT "A strategy for precise and large scale identification of core fucosylated
RT glycoproteins.";
RL Mol. Cell. Proteomics 8:913-923(2009).
CC -!- INTERACTION:
CC Q9BXJ4; P42858: HTT; NbExp=3; IntAct=EBI-10697546, EBI-466029;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9BXJ4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BXJ4-2; Sequence=VSP_011624, VSP_011625;
CC Name=3;
CC IsoId=Q9BXJ4-3; Sequence=VSP_043157;
CC -!- TISSUE SPECIFICITY: Expressed in colon and small intestine.
CC {ECO:0000269|PubMed:14654242}.
CC -!- PTM: [Isoform 3]: Glycosylated on Asn-70.
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DR EMBL; AF329837; AAK17961.1; -; mRNA.
DR EMBL; AF326976; AAK70344.1; -; mRNA.
DR EMBL; EU399231; ABY86416.1; -; mRNA.
DR EMBL; EU399232; ABY86417.1; -; mRNA.
DR EMBL; AY358388; AAQ88754.1; -; mRNA.
DR EMBL; AK295968; BAG58744.1; -; mRNA.
DR EMBL; AK315921; BAH14292.1; -; mRNA.
DR EMBL; AK075533; BAC11676.1; -; mRNA.
DR EMBL; BX640995; CAE45998.1; -; mRNA.
DR EMBL; AC139783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC139792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471118; EAX10820.1; -; Genomic_DNA.
DR EMBL; BC112925; AAI12926.1; -; mRNA.
DR EMBL; BC120990; AAI20991.1; -; mRNA.
DR EMBL; AF173888; AAQ13635.1; -; mRNA.
DR CCDS; CCDS34141.1; -. [Q9BXJ4-3]
DR CCDS; CCDS3904.1; -. [Q9BXJ4-1]
DR RefSeq; NP_112207.1; NM_030945.3. [Q9BXJ4-1]
DR RefSeq; NP_852100.3; NM_181435.5. [Q9BXJ4-3]
DR AlphaFoldDB; Q9BXJ4; -.
DR SMR; Q9BXJ4; -.
DR BioGRID; 125390; 12.
DR IntAct; Q9BXJ4; 4.
DR STRING; 9606.ENSP00000371497; -.
DR GlyCosmos; Q9BXJ4; 1 site, No reported glycans.
DR GlyGen; Q9BXJ4; 1 site.
DR iPTMnet; Q9BXJ4; -.
DR PhosphoSitePlus; Q9BXJ4; -.
DR BioMuta; C1QTNF3; -.
DR jPOST; Q9BXJ4; -.
DR MassIVE; Q9BXJ4; -.
DR PeptideAtlas; Q9BXJ4; -.
DR ProteomicsDB; 79436; -. [Q9BXJ4-1]
DR ProteomicsDB; 79437; -. [Q9BXJ4-2]
DR ProteomicsDB; 79438; -. [Q9BXJ4-3]
DR Pumba; Q9BXJ4; -.
DR Antibodypedia; 3524; 167 antibodies from 31 providers.
DR DNASU; 114899; -.
DR Ensembl; ENST00000231338.7; ENSP00000231338.7; ENSG00000082196.21. [Q9BXJ4-1]
DR Ensembl; ENST00000382065.8; ENSP00000371497.3; ENSG00000082196.21. [Q9BXJ4-3]
DR GeneID; 114899; -.
DR KEGG; hsa:114899; -.
DR MANE-Select; ENST00000382065.8; ENSP00000371497.3; NM_181435.6; NP_852100.3. [Q9BXJ4-3]
DR UCSC; uc003jin.4; human. [Q9BXJ4-1]
DR AGR; HGNC:14326; -.
DR CTD; 114899; -.
DR DisGeNET; 114899; -.
DR GeneCards; C1QTNF3; -.
DR HGNC; HGNC:14326; C1QTNF3.
DR HPA; ENSG00000082196; Tissue enhanced (esophagus, salivary gland).
DR MIM; 612045; gene.
DR neXtProt; NX_Q9BXJ4; -.
DR OpenTargets; ENSG00000082196; -.
DR PharmGKB; PA25630; -.
DR VEuPathDB; HostDB:ENSG00000082196; -.
DR eggNOG; ENOG502QSK2; Eukaryota.
DR GeneTree; ENSGT00940000161378; -.
DR HOGENOM; CLU_001074_0_1_1; -.
DR InParanoid; Q9BXJ4; -.
DR OMA; KVAFMAS; -.
DR OrthoDB; 4208355at2759; -.
DR PhylomeDB; Q9BXJ4; -.
DR TreeFam; TF329591; -.
DR PathwayCommons; Q9BXJ4; -.
DR SignaLink; Q9BXJ4; -.
DR BioGRID-ORCS; 114899; 8 hits in 1142 CRISPR screens.
DR ChiTaRS; C1QTNF3; human.
DR GeneWiki; C1QTNF3; -.
DR GenomeRNAi; 114899; -.
DR Pharos; Q9BXJ4; Tbio.
DR PRO; PR:Q9BXJ4; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9BXJ4; Protein.
DR Bgee; ENSG00000082196; Expressed in parotid gland and 163 other cell types or tissues.
DR Genevisible; Q9BXJ4; HS.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:UniProtKB.
DR GO; GO:0045444; P:fat cell differentiation; IEP:UniProtKB.
DR GO; GO:0035356; P:intracellular triglyceride homeostasis; IDA:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; IDA:UniProtKB.
DR GO; GO:0045721; P:negative regulation of gluconeogenesis; IDA:UniProtKB.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IDA:UniProtKB.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IDA:UniProtKB.
DR GO; GO:0071638; P:negative regulation of monocyte chemotactic protein-1 production; IDA:UniProtKB.
DR GO; GO:1901223; P:negative regulation of non-canonical NF-kappaB signal transduction; IDA:UniProtKB.
DR GO; GO:0070165; P:positive regulation of adiponectin secretion; IDA:UniProtKB.
DR GO; GO:0001819; P:positive regulation of cytokine production; IDA:UniProtKB.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427:SF49; C1Q DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Collagen; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..246
FT /note="Complement C1q tumor necrosis factor-related protein
FT 3"
FT /id="PRO_0000003531"
FT DOMAIN 51..113
FT /note="Collagen-like"
FT DOMAIN 113..246
FT /note="C1q"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT REGION 53..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 28
FT /note="E -> EVSGRTNKVVARIVQSHQQTGRSGSRREKVRERSHPKTGTVDNNTST
FT DLKSLRPDELPHPEVDDLAQITTFWGQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:20952387"
FT /id="VSP_043157"
FT VAR_SEQ 46..69
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_011624"
FT VAR_SEQ 82..105
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_011625"
FT CARBOHYD Q9BXJ4-3:70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
SQ SEQUENCE 246 AA; 26994 MW; C589B6C3A73E5D29 CRC64;
MLWRQLIYWQ LLALFFLPFC LCQDEYMESP QTGGLPPDCS KCCHGDYSFR GYQGPPGPPG
PPGIPGNHGN NGNNGATGHE GAKGEKGDKG DLGPRGERGQ HGPKGEKGYP GIPPELQIAF
MASLATHFSN QNSGIIFSSV ETNIGNFFDV MTGRFGAPVS GVYFFTFSMM KHEDVEEVYV
YLMHNGNTVF SMYSYEMKGK SDTSSNHAVL KLAKGDEVWL RMGNGALHGD HQRFSTFAGF
LLFETK
//
