ID C2EG52_9LACO Unreviewed; 876 AA.
AC C2EG52;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:EEJ74420.1};
GN ORFNames=HMPREF0545_0624 {ECO:0000313|EMBL:EEJ74420.1};
OS Ligilactobacillus salivarius DSM 20555 = ATCC 11741.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=1423799 {ECO:0000313|EMBL:EEJ74420.1, ECO:0000313|Proteomes:UP000003531};
RN [1] {ECO:0000313|EMBL:EEJ74420.1, ECO:0000313|Proteomes:UP000003531}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11741 {ECO:0000313|EMBL:EEJ74420.1,
RC ECO:0000313|Proteomes:UP000003531};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEJ74420.1}.
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DR EMBL; ACGT01000004; EEJ74420.1; -; Genomic_DNA.
DR RefSeq; WP_003700564.1; NZ_GG693223.1.
DR AlphaFoldDB; C2EG52; -.
DR PATRIC; fig|1423799.3.peg.804; -.
DR HOGENOM; CLU_002472_1_3_9; -.
DR Proteomes; UP000003531; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 683..699
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 801..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 609..616
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 876 AA; 99535 MW; 72858C15C851479F CRC64;
MPQKTKQTPM MEQYMQIKKQ YPDAFLFYRL GDFYEMFYDD AIKGSQILEL TLTQRNKKAV
DPIPMCGVPH HAAQNYIDIL VDKGYKVAIC EQVEDPKQAK GMVKREVIQL VTPGTIIDES
AGEAKENNYL TALHFENNQY GFAYVDLSTG ELKVSVLNTI DTILNELISL RTKEIVVDSS
VNDEVLNQIK NLKILISEQN DTEDSSEVSF ASQDVENSVE VEVIKHLITY LKITQKRALS
HLQRAVHYEP SQYLKMDYHA KRNLELLRNL RTQKKSGTLL WLLDSTKTAM GGRLLKQWID
RPLINLKEIE ARQSMVENLL THYFERSGLQ EELVNVYDLE RLAGKVAFGS VNGRDLIQLR
TSLEHIPQIR YIIQELNNDS TFDEIFDKLD PIEDIADLIE QAIEDEPPIS VTDGNLIKPG
YSQELDEYVD AMKNGKAWLA ELEAKERQAT GINNLKIGFN RVFGYYIEVS KGNLSKLPED
RYQRKQTLTN AERFITPELK EKESLILGAE SKAKELEYKI FTGIRDQIKD EIQRIQELAG
AVAALDVLQS FATVSEQGHF VKPELTTDNH SLDIKDGWHP VVEKVMGKQS YIPNDIKMDD
DLDVLLITGP NMSGKSTYMR QLALTVVIAQ IGCFVPAKSA KMPIFDQIFT RIGAADDLIS
GESTFMVEMK ETNVALMNAT RNSLLLFDEI GRGTATYDGM ALAQAIIEYV HNNIHAKTLF
STHYHELTIL DESLDKLQNV HVGAIEKNGE LIFLHKMQEG PADKSYGIHV AKLAGMPDKL
LKRADSILNK LESENDFTVE STESYTEEKH IEEKNENETS EIQEEQLSLF QPEAVSLDSN
QSKILKEIKN ANLMGMTPMD VMNIVFKWQK ELNKKG
//
