ID C2KK55_LEUMC Unreviewed; 854 AA.
AC C2KK55;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:EEJ42369.1};
GN ORFNames=HMPREF0555_1021 {ECO:0000313|EMBL:EEJ42369.1};
OS Leuconostoc mesenteroides subsp. cremoris ATCC 19254.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Leuconostoc.
OX NCBI_TaxID=586220 {ECO:0000313|EMBL:EEJ42369.1, ECO:0000313|Proteomes:UP000004283};
RN [1] {ECO:0000313|EMBL:EEJ42369.1, ECO:0000313|Proteomes:UP000004283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19254 {ECO:0000313|EMBL:EEJ42369.1,
RC ECO:0000313|Proteomes:UP000004283};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEJ42369.1}.
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DR EMBL; ACKV01000049; EEJ42369.1; -; Genomic_DNA.
DR RefSeq; WP_002815328.1; NZ_GG693383.1.
DR AlphaFoldDB; C2KK55; -.
DR HOGENOM; CLU_002472_4_0_9; -.
DR Proteomes; UP000004283; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 682..698
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 608..615
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 854 AA; 95419 MW; 9C08C3FECAD8F604 CRC64;
MAKVAETPMM VQYHEIKSQY PDAFVFYRLG DFYELFEDDA VLGAKLLELT LTARNKNSEN
PVPMAGIPHH AAQNYIDILV DQGHKVAIVE QMEDPATAKG MVKRDVVQLI TPGTKLNSGM
GNDKQNNYLA AVLPRDNRYF LSYIDLSTGE LKTTTLKRFS DVIDELSSLE VKEIVLLKDD
ETTELGIANK LAERGLVIST QSDVNVNATV SFLTQPLVHE NEAQVTTILL NYIFDTQRRN
LDHIIPAQNY ERLAYLKFNQ DTRTNLDLVK NARTKKKAGS LLGLIDETKT AMGGRLLKQW
LLRPLRDTED INERLDVIEA FQNEFFVRGA LQDHLKSVYD LERLAARAAM GTMNARELVQ
LKRSLSAIPG MKSVLSSSQG ILNHASQRLE DMSDLAGLID EAIVDDPPIS IREGDIINDG
FDSKIDEYRN VLSQNQKWLA QLESDERAAT GINSLKVKYN KNFGFFIEVS RANVSKLEEG
RYERKQTLTN AERFVTPELK EHERLINEAQ LKRTEREYEL FITIRERFKA NISRLQKLAR
QVAQLDVLAS LADVSDNNRF VRPTFTDDNI INIKQGRHPV VEAILEAGEF VANDVNLDQN
TAMQLITGPN MAGKSTYMRE LALIVILGQM GSFVPAESAV LPIFDQIFTR IGANDDMAMG
QSTFMVEMAE ANLALQEASA HSLILFDELG RGTATYDGMA LAQAIIEYLD AHVHAKTLFS
THYHELTALV DKHENIKNVH VGAVEDESGE LHFLHQIQQG PADKSYGIHV AALAGLPDEL
IANATTILSG LENQEALVPE PKASGLSEQA ALFNVSDVDP KTETLFQKLD SINISTMTPL
EALNVLAELQ KLRK
//
