ID C2NLP3_BACCE Unreviewed; 296 AA.
AC C2NLP3;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=Ribosome biogenesis GTPase A {ECO:0000256|ARBA:ARBA00014898, ECO:0000256|PIRNR:PIRNR006230};
GN ORFNames=bcere0004_36250 {ECO:0000313|EMBL:EEK54905.1};
OS Bacillus cereus BGSC 6E1.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=526970 {ECO:0000313|EMBL:EEK54905.1};
RN [1] {ECO:0000313|EMBL:EEK54905.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGSC 6E1 {ECO:0000313|EMBL:EEK54905.1};
RX PubMed=22645259; DOI=10.1101/gr.134437.111;
RA Zwick M.E., Joseph S.J., Didelot X., Chen P.E., Bishop-Lilly K.A.,
RA Stewart A.C., Willner K., Nolan N., Lentz S., Thomason M.K.,
RA Sozhamannan S., Mateczun A.J., Du L., Read T.D.;
RT "Genomic characterization of the Bacillus cereus sensu lato species:
RT Backdrop to the evolution of Bacillus anthracis.";
RL Genome Res. 22:1512-1524(2012).
CC -!- FUNCTION: Essential protein that is required for a late step of 50S
CC ribosomal subunit assembly. Has GTPase activity that is stimulated by
CC interaction with the immature 50S ribosome subunit. Binds to the 23S
CC rRNA. Required for the association of ribosomal proteins rplP and rpmA
CC with the large subunit. {ECO:0000256|ARBA:ARBA00025021}.
CC -!- FUNCTION: Required for a late step of 50S ribosomal subunit assembly.
CC Has GTPase activity. {ECO:0000256|PIRNR:PIRNR006230}.
CC -!- SUBUNIT: Interacts with ctc. Interacts with the immature 50S ribosome
CC subunit. 2 molecules of rbgA bind to one 50S subunit.
CC {ECO:0000256|ARBA:ARBA00025856}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006230}.
CC -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1
CC subfamily. {ECO:0000256|PIRNR:PIRNR006230}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEK54905.1}.
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DR EMBL; ACLU01000086; EEK54905.1; -; Genomic_DNA.
DR RefSeq; WP_000236696.1; NZ_CM000716.1.
DR AlphaFoldDB; C2NLP3; -.
DR HOGENOM; CLU_011106_1_0_9; -.
DR Proteomes; UP000000284; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR CDD; cd01856; YlqF; 1.
DR Gene3D; 1.10.1580.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR InterPro; IPR019991; GTP-bd_ribosome_bgen.
DR InterPro; IPR016478; GTPase_MTG1.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR03596; GTPase_YlqF; 1.
DR PANTHER; PTHR45782; MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1; 1.
DR PANTHER; PTHR45782:SF4; MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PIRSF; PIRSF006230; MG442; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR006230};
KW GTP-binding {ECO:0000256|PIRNR:PIRNR006230, ECO:0000256|PIRSR:PIRSR006230-
KW 1};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR006230,
KW ECO:0000256|PIRSR:PIRSR006230-1};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517}.
FT DOMAIN 14..178
FT /note="CP-type G"
FT /evidence="ECO:0000259|PROSITE:PS51721"
FT BINDING 58..61
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|PIRSR:PIRSR006230-1"
FT BINDING 130..135
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|PIRSR:PIRSR006230-1"
FT BINDING 174
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|PIRSR:PIRSR006230-1"
SQ SEQUENCE 296 AA; 33337 MW; 9C05A5051872DC92 CRC64;
MVIQWFPGHM AKARRQVTEK LKLIDVVIEL VDARLPLSSR NPMIDEIITH KPRLVVLNKA
DMADDRLTKQ WIAYFKEKGH MAISINAQAG QGMKEIAAAC KVLVKEKFDK MVAKGIRPRA
IRALIVGIPN VGKSTLINKL AKKNIAKTGD RPGVTTAQQW IKVGKEMELL DTPGILWPKF
EDELVGLRLA TTGAIKDSIL NLQDVAVYAL RFMEKHYPER LKERYNLNDI PEDIVELFDA
IGKNRGCLMG GGMIDYDKTS ELVLRELRGG KLGKMTFETP EEFAEQTEDA EKVEEV
//
